The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line
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Marine Natural Products as Models to Circumvent Multidrug ResistanceCapillary nano-immunoassays: advancing quantitative proteomics analysis, biomarker assessment, and molecular diagnosticsA Phase II Trial of AZD6244 (Selumetinib, ARRY-142886), an Oral MEK1/2 Inhibitor, in Relapsed/Refractory Multiple MyelomaSynthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone coreMolecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligandsLoss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activityNeristatin 1 provides critical insight into bryostatin 1 structure-function relationshipsConformation-activity relationships of polyketide natural products.Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system.Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesionsReal-time nanoscale proteomic analysis of the novel multi-kinase pathway inhibitor rigosertib to measure the response to treatment of cancer.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin.
P2860
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P2860
The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
The synthetic bryostatin analo ...... uman prostate cancer cell line
@ast
The synthetic bryostatin analo ...... uman prostate cancer cell line
@en
The synthetic bryostatin analo ...... uman prostate cancer cell line
@nl
type
label
The synthetic bryostatin analo ...... uman prostate cancer cell line
@ast
The synthetic bryostatin analo ...... uman prostate cancer cell line
@en
The synthetic bryostatin analo ...... uman prostate cancer cell line
@nl
prefLabel
The synthetic bryostatin analo ...... uman prostate cancer cell line
@ast
The synthetic bryostatin analo ...... uman prostate cancer cell line
@en
The synthetic bryostatin analo ...... uman prostate cancer cell line
@nl
P2093
P2860
P1476
The synthetic bryostatin analo ...... uman prostate cancer cell line
@en
P2093
Alexandra Czap
Andrea Telek
Dazhi Yang
Emanuel S Lubart
Gabriella Czifra
Gary E Keck
Jinqiu Chen
Langston Lim
Matthew B Kraft
Noemi Kedei
P2860
P304
P356
10.1016/J.BCP.2011.03.018
P407
P577
2011-03-30T00:00:00Z