Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
about
New Drugs from Marine Organisms in Alzheimer's DiseaseSynthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone coreComparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities.Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC.Syntheses of C17-C27 fragments of 20-deoxybryostatins for assembly using Julia and metathesis reactions.Total synthesis of 7-des-O-pivaloyl-7-O-benzylbryostatin 10.Synthetic approaches to the C11-C27 fragments of bryostatins.The evolution of a stereoselective synthesis of the C1-C16 fragment of bryostatins.Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin.
P2860
Q26771804-B1BE4D37-A779-4985-9035-D86216C8A139Q34282542-CF349168-12D4-469D-B17F-99D45C984344Q34282624-125FA225-72D6-49B6-9C7C-FF23D9CB612AQ36557113-E2EB4359-77AE-4B47-B041-9A882E381B3AQ38200047-13A1D695-ADE9-46CE-84B7-4DE2DB81D20CQ38707861-9A47D77C-D7DC-4C67-96FB-D1D9B10B3EFFQ42135531-355DB1D4-AA0A-470D-B20F-2ACF08D371A1Q42388442-673E00DB-8E72-44F6-B438-2ADE736B1ADEQ48152462-AEE7B6EC-9F5C-4936-AD3F-25A576ECDCA0Q50130105-E6F798E5-DD73-4E0F-B617-EC301F28CCFAQ50130124-A4885E74-B526-4260-AA0F-A397FEE2D189Q52845242-D7705039-415C-4963-AAC7-42F2E5E61EC5Q53179835-64FD00F9-7741-493E-9C3F-4958DAEDA17E
P2860
Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Role of the C8 gem-dimethyl gr ...... attern of biological activity.
@en
Role of the C8 gem-dimethyl gr ...... attern of biological activity.
@nl
type
label
Role of the C8 gem-dimethyl gr ...... attern of biological activity.
@en
Role of the C8 gem-dimethyl gr ...... attern of biological activity.
@nl
prefLabel
Role of the C8 gem-dimethyl gr ...... attern of biological activity.
@en
Role of the C8 gem-dimethyl gr ...... attern of biological activity.
@nl
P2093
P2860
P1476
Role of the C8 gem-dimethyl gr ...... attern of biological activity.
@en
P2093
Arnab Rudra
Gary E Keck
Jeffrey C Stephens
Nancy E Lewin
Noemi Kedei
Peter M Blumberg
Yam B Poudel
P2860
P304
P356
10.1016/J.BMCL.2012.04.073
P407
P577
2012-04-24T00:00:00Z