Mastl kinase, a promising therapeutic target, promotes cancer recurrence. - Wikidata - awgldk - TriplyDB

Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

http://www.wikidata.org/entity/Q34957406

about

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening Cell fate determination in cisplatin resistance and chemosensitization Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining.Cell cycle-dependent regulation of Greatwall kinase by protein phosphatase 1 and regulatory subunit 3B.Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer.Identification of new inhibitors against human Great wall kinase using in silico approaches.Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer.MASTL overexpression promotes chromosome instability and metastasis in breast cancer.MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells.MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

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P2860

Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

http://www.wikidata.org/entity/Q34957406

description

2014 nî lūn-bûn

@nan

2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

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Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

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Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

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type

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Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

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Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

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Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

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prefLabel

Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

@ast

Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

@en

Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

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ONCOTARGET.2565

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Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

@en

P2093

Aimin Peng

http://www.w3.org/2001/XMLSchema#string

Ling Wang

http://www.w3.org/2001/XMLSchema#string

Peter J Giannini

http://www.w3.org/2001/XMLSchema#string

Vivian Q Luong

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P2860

MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis

The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

Mutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with Polo kinase

DNA double-strand breaks: signaling, repair and the cancer connection

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

Cell cycle kinases in cancer

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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10.18632/ONCOTARGET.2565

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22

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