UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement
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UVB-induced apoptosis drives clonal expansion during skin tumor developmentReconstructing skin cancers using animal modelsTranscriptome sequencing reveals genome-wide variation in molecular evolutionary rate among fernsIARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation toolsStochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia.Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells.Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer.Melanoma and sun exposure: where are we now?Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis.Carcinogenesis in mouse and human cells: parallels and paradoxes.Photoprotective actions of topically applied vitamin E.P53 mutations associated with breast, colorectal, liver, lung, and ovarian cancersFuture research directions in the use of biomarkersMolecular epidemiology in environmental health: the potential of tumor suppressor gene p53 as a biomarker.Relationship of p53 mutations to epidermal cell proliferation and apoptosis in human UV-induced skin carcinogenesis.Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment.Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair.A novel radiation-induced p53 mutation is not implicated in radiation resistance via a dominant-negative effect.Ligation of high-melting-temperature 'clamp' sequence extends the scanning range of rare point-mutational analysis by constant denaturant capillary electrophoresis (CDCE) to most of the human genome.From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma.Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.Frequent clones of p53-mutated keratinocytes in normal human skinSunlight and skin cancer: another link revealedp53 and the pathogenesis of skin cancer.Keratinocyte apoptosis in epidermal development and disease.Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwanp53 tumor suppressor gene: a critical molecular target for UV induction and prevention of skin cancer.Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22.Current treatment of cutaneous squamous cancer and molecular strategies for its sensitization to new target-based drugs.Synergism between mTOR pathway and ultraviolet radiation in the pathogenesis of squamous cell carcinoma and its implication for solid-organ transplant recipients.Pharmacologic treatment options for advanced epithelial skin cancer.Pathways to Genome-targeted Therapies in Serous Ovarian Cancer.Protective effects of Polypodium leucotomos extract against UVB-induced damage in a model of reconstructed human epidermis.UVB-Induced p21 degradation promotes apoptosis of human keratinocytes.Identification and characterization of a novel cross-link lesion in d(CpC) upon 365-nm irradiation in the presence of 2-methyl-1,4-naphthoquinone.An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.Gain of 11q/cyclin D1 overexpression is an essential early step in skin cancer development and causes abnormal tissue organization and differentiation.p53 gene mutations and photocarcinogenesis.Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes.Use of the alkaline comet assay to detect DNA repair deficiencies in human fibroblasts exposed to UVC, UVB, UVA and gamma-rays.
P2860
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P2860
UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
UV and skin cancer: specific p ...... relevant exposure measurement
@ast
UV and skin cancer: specific p ...... relevant exposure measurement
@en
UV and skin cancer: specific p ...... relevant exposure measurement
@nl
type
label
UV and skin cancer: specific p ...... relevant exposure measurement
@ast
UV and skin cancer: specific p ...... relevant exposure measurement
@en
UV and skin cancer: specific p ...... relevant exposure measurement
@nl
prefLabel
UV and skin cancer: specific p ...... relevant exposure measurement
@ast
UV and skin cancer: specific p ...... relevant exposure measurement
@en
UV and skin cancer: specific p ...... relevant exposure measurement
@nl
P2093
P2860
P356
P1476
UV and skin cancer: specific p ...... relevant exposure measurement
@en
P2093
H Nakazawa
H Yamasaki
K Nakazawa
P L Randell
P2860
P304
P356
10.1073/PNAS.91.1.360
P407
P577
1994-01-01T00:00:00Z