Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. - Wikidata - awgldk - TriplyDB

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.

http://www.wikidata.org/entity/Q34974604

about

Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance T cell activation Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance Central tolerance: learning self-control in the thymus Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.c-Cbl-mediated regulation of LAT-nucleated signaling complexes Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.Lipid signaling in T-cell development and function The importance of LAT in the activation, homeostasis, and regulatory function of T cells RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4 Immunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling.A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection.In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation.Targeted Sos1 deletion reveals its critical role in early T-cell development.Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.LAT-mediated signaling in CD4+CD25+ regulatory T cell development.Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.The role of the LAT-PLC-gamma1 interaction in T regulatory cell function.A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity Compartmentalization of ITAM and integrin signaling by adapter molecules.Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.The janus head of T cell aging - autoimmunity and immunodeficiency.Lymphocyte signaling: beyond knockouts.Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Origin of the sharp boundary that discriminates positive and negative selection of thymocytes T cell Receptor Signal Transduction in T lymphocytes.The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage Bam32: a novel mediator of Erk activation in T cells.Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.The calcium/NFAT pathway: role in development and function of regulatory T cells.Regulation of lymphocyte development and activation by the LAT family of adapter proteins.The balancing act of autoimmunity: central and peripheral tolerance versus infection control.The LAT story: a tale of cooperativity, coordination, and choreography.

P2860

Q24304214-518E7AB6-14FB-47A4-B58C-E8592221B3D9 Q24642248-C79F5AD8-D755-499F-81F9-89A76FE8C3BA Q24658051-E8F348C9-E47E-4098-95C9-489044FCFB48 Q28269352-13E78E41-A0F1-4582-A349-D8957763299E Q28275215-51DF91D4-F259-4228-888C-A82A0BE7B2EC Q30159670-492EA0AC-2183-43FE-AA30-DE0665B3ABD6 Q30480971-8D442445-BE0A-49BA-8436-CD4FDC10AF54 Q33597132-4FAEDAAA-B833-4057-9696-8BE2BCE708FA Q33656136-766CE096-117C-4322-8AB7-8671235DAAED Q34060500-EA2F9EF1-3634-4D6D-A20D-59C9EA428CF8 Q34140008-7D7536CF-AE59-420A-996E-C2E6098E0C48 Q34241131-BEEC20BA-7676-447D-8E86-9265EAA01F0B Q34285036-0E8712C1-C024-4554-BB6E-24776069722A Q34544903-540507B7-0F05-4A6B-9DA4-CD175D4E6233 Q34625945-E10152C1-C74B-4513-A9AD-D2A7A51B1D37 Q34666349-AD867E30-E99A-4C41-BD5C-07F1ADE34208 Q34997154-1289B1A7-AF8B-4921-80D4-DF41F7D0D531 Q35035235-C3330E9B-B9AC-450E-B60A-F09D1E124E64 Q35134263-C5D63DA4-98F8-4655-8EAD-0DBE772D487F Q35184781-6D76900C-CE22-443A-A38C-723BA9516D72 Q36070023-B4658237-6E21-43CF-B110-18F2DBB6DDE3 Q36227859-976810FC-BBD7-4BAB-A8DB-9521D51B3965 Q36278062-83DC24A2-6104-4C68-9E2E-F0A81D94110D Q36487572-0CEC8188-A1EA-4D1D-980D-FFF77FD5232E Q36822300-4490D37F-4637-4BBC-98B5-182C9D75DE16 Q36822312-4DCDA49C-3B54-4A5C-AE9B-F780980531BE Q36877284-28A396D2-059D-4846-809E-905C881ACA01 Q36892161-94F7D05F-9430-455C-8811-CD0BFBE9DAF4 Q36898613-956B25FA-E357-43C4-A305-048FA7A6EF47 Q36982685-AF93D912-E0A6-434F-88FC-2A3A9EEEED72 Q37047281-F677EB2B-4B76-47E3-A35E-E1C6FC664E31 Q37062064-9A24F7DF-73F0-4FA3-A68A-81EAC5B1617D Q37087575-93E58C48-7EAB-4928-8E6E-4D411E88C539 Q37166773-D99B0FF0-AD98-453F-BABD-0B916183536B Q37188427-AECF8D31-C3A9-4D8F-BB6C-536350C9F512 Q37376338-B924D66A-1D59-42C4-B0B7-E890885DF33D Q37449706-AECB9567-83A7-41C1-9168-75A3BB901BD9 Q37631692-130C7692-81D8-4870-B282-450FAE9D7B44 Q37724190-011FE3C2-4E42-45DA-8455-7CFDB80EF0C2 Q37770817-7918A988-7024-4002-A3E8-4410AE931B0D

P2860

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.

http://www.wikidata.org/entity/Q34974604

description

2005 nî lūn-bûn

@nan

2005 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի մարտին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Mutation of the phospholipase ...... negative thymocyte selection.

@ast

Mutation of the phospholipase ...... negative thymocyte selection.

@en

Mutation of the phospholipase ...... negative thymocyte selection.

@nl

type

label

Mutation of the phospholipase ...... negative thymocyte selection.

@ast

Mutation of the phospholipase ...... negative thymocyte selection.

@en

Mutation of the phospholipase ...... negative thymocyte selection.

@nl

prefLabel

Mutation of the phospholipase ...... negative thymocyte selection.

@ast

Mutation of the phospholipase ...... negative thymocyte selection.

@en

Mutation of the phospholipase ...... negative thymocyte selection.

@nl

P1433

Q34974604-533827EC-EEBB-44D7-B474-1964C8CB0198

P1476

Q34974604-2D81E94E-1EB5-4693-9F54-2E1C1CB9B556

P2093

Q34974604-149D37D0-D789-4A5C-99B8-D01E8BE0E082

Q34974604-2380B108-AD7F-4D74-BFDB-80404196E4CB

Q34974604-5C053947-7509-417E-A5C5-81332E2A170F

Q34974604-657D00FA-0071-4E74-823F-FC0A96BD6DF8

Q34974604-68F585DA-2365-46D9-B0AD-BE180CE7FAC3

Q34974604-B9FFDE0D-07CA-4944-9EC0-B5F19347515A

Q34974604-BC703EC1-8F9B-4BFB-A169-FA76E5F7461A

Q34974604-D5294F0B-ED33-43C1-802E-2E0639EFA542

Q34974604-D68E22C3-A694-4508-B8BD-F9009E6A87B3

Q34974604-ECC32ECB-EED9-491E-BBB7-C3E80AB47DC7

P2860

Q34974604-01609F8B-4908-45A0-B1C7-B1EA71AA96F0

Q34974604-0198C52D-B949-42DC-89CE-143E4FAC9E67

Q34974604-03937571-824F-4DF9-85BD-ED3EA710A575

Q34974604-048BF621-D94D-4DBB-8AA1-5043B50A0AC9

Q34974604-05DF6C38-7351-4B55-AD06-FE664EFFD94E

Q34974604-1E878A50-1A09-4143-8308-599F64033CB2

Q34974604-2131C735-C32E-4EF1-A0C0-E624E9EC697F

Q34974604-2193D41A-CB99-4925-BE30-B2C2443EE407

Q34974604-22F4B3CB-1AE3-4C63-BC89-04D12ADB204F

Q34974604-25408A88-F5A6-47F3-BAA8-6EDC30B4B137

P304

Q34974604-C4D21CE5-2841-49FD-B917-1E76AAD566B3

P31

Q34974604-8E0F2F54-E34E-4021-8994-106F96BC4CA0

P356

Q34974604-B134B60D-B72C-43D4-9291-815A8E38B8E5

P407

Q34974604-32E694E8-BC6E-4F1A-AF26-657B0ADCA305

P433

Q34974604-A28C6700-B029-4838-8926-3EC7997A4EB3

P478

Q34974604-6E00D4B8-DDEB-420C-9E06-7BE8DA85F9B6

P577

Q34974604-B9085422-0501-4B3E-B278-39D5906A4624

P5875

Q34974604-0C21A5DB-728C-444D-8CD8-B4F7F4803A26

P698

Q34974604-EE67D300-E45F-443C-B47C-25FFD22109A4

P932

Q34974604-564957B6-9ABE-4213-8DDE-F2F4D80F9A1F

P356

P1433

Journal of Experimental Medicine

P1476

Mutation of the phospholipase ...... negative thymocyte selection.

@en

P2093

Claudette L Fuller

http://www.w3.org/2001/XMLSchema#string

Connie L Sommers

http://www.w3.org/2001/XMLSchema#string

Corinne L Depersis

http://www.w3.org/2001/XMLSchema#string

Dalal El-Khoury

http://www.w3.org/2001/XMLSchema#string

Elizabeth W Shores

http://www.w3.org/2001/XMLSchema#string

Jan Lee

http://www.w3.org/2001/XMLSchema#string

Jordan M Gurson

http://www.w3.org/2001/XMLSchema#string

Kevin L Steiner

http://www.w3.org/2001/XMLSchema#string

Lawrence E Samelson

http://www.w3.org/2001/XMLSchema#string

Paul E Love

http://www.w3.org/2001/XMLSchema#string

P2860

RasGRP links T-cell receptor signaling to Ras

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT

LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways

LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways

Signals involved in thymocyte positive and negative selection.

T cell activation and the cytoskeleton.

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins.

Positive and negative selection of T cells.

P304

1125-1134

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1084/JEM.20041869

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

201

http://www.w3.org/2001/XMLSchema#string

P577

2005-03-28T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7941194

http://www.w3.org/2001/XMLSchema#string

P698

15795236

http://www.w3.org/2001/XMLSchema#string

P932

1538971

http://www.w3.org/2001/XMLSchema#string