Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression - Wikidata - awgldk - TriplyDB

Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression

Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression

http://www.wikidata.org/entity/Q34991077

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The role of oxidative stress in Parkinson's disease A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models Dopamine and paraquat enhance α-synuclein-induced alterations in membrane conductance PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice Evidence for early and progressive ultrasonic vocalization and oromotor deficits in a PINK1 gene knockout rat model of Parkinson's disease Atp13a2 expression in the periaqueductal gray is decreased in the Pink1 -/- rat model of Parkinson disease.Vocalization deficits in mice over-expressing alpha-synuclein, a model of pre-manifest Parkinson's disease.Strengths and limitations of genetic mouse models of Parkinson's disease.Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein.A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions.Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synuclein Gene-environment interactions in Parkinson's disease: the importance of animal modeling.Olfactory deficits in mice overexpressing human wildtype alpha-synuclein.Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.Traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquat.A GCase chaperone improves motor function in a mouse model of synucleinopathy.A guide to neurotoxic animal models of Parkinson's disease Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease Differential regional expression patterns of α-synuclein, TNF-α, and IL-1β; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment.Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression.α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice.Animal models of the non-motor features of Parkinson's disease.Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice.Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein Animal models of Parkinson's disease progression In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway.Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein.Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage.Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.Caspase-1 clipping causes complications for α-synuclein.

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Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression

http://www.wikidata.org/entity/Q34991077

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2007 nî lūn-bûn

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2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Behavioral and histopathologic ...... lpha-synuclein over-expression

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Behavioral and histopathologic ...... lpha-synuclein over-expression

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C B Hutson

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E Masliah

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J Salcedo

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N A Tetreaut

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S M Fleming

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P2860

Staging of brain pathology related to sporadic Parkinson's disease

Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Ageing and Parkinson's disease: substantia nigra regional selectivity

Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.

Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism.

The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration.

Design-based stereological methods for counting neurons.

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10.1002/SYN.20456

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12

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61

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