G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation.
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ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinomaEvolution and dynamics of pancreatic cancer progressionTransforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cellsSmad4-expression is decreased in breast cancer tissues: a retrospective study.Mechanism for mutational inactivation of the tumor suppressor Smad2.MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4.MicroRNA-205 targets SMAD4 in non-small cell lung cancer and promotes lung cancer cell growth in vitro and in vivo.Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4.SMAD4 is a potential prognostic marker in human breast carcinomas.Meta-analysis of the prognostic value of smad4 immunohistochemistry in various cancers.An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis.Molecular pathways in pancreatic carcinogenesisLoss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis.Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis.The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations.Nuclear localization of Dpc4 (Madh4, Smad4) in colorectal carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defectsTransforming growth factor-beta 1 induces apoptosis through Fas ligand-independent activation of the Fas death pathway in human gastric SNU-620 carcinoma cells.TGF-beta1 attenuates mediator release and de novo Kit expression by human skin mast cells through a Smad-dependent pathwayInhibition of pancreatic carcinoma cell growth in vitro by DPC4 gene transfection.Current mouse and cell models in prostate cancer research.Dichotomous roles of TGF-β in human cancer.Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers.Identification of apoptotic genes mediating TGF-beta/Smad3-induced cell death in intestinal epithelial cells using a genomic approach.Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors.Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells.Personalized medicine in pancreatic cancer: prognosis and potential implications for therapy.Adenovirus-mediated gene transfer of dominant-negative Smad4 blocks TGF-beta signaling in pancreatic acinar cells.Loss of Function of SMAD4 in CancerRestoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.
P2860
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P2860
G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation.
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
G1 cell cycle arrest and apopt ...... sed by a tumorigenic mutation.
@ast
G1 cell cycle arrest and apopt ...... sed by a tumorigenic mutation.
@en
G1 cell cycle arrest and apopt ...... sed by a tumorigenic mutation.
@nl
type
label
G1 cell cycle arrest and apopt ...... sed by a tumorigenic mutation.
@ast
G1 cell cycle arrest and apopt ...... sed by a tumorigenic mutation.
@en
G1 cell cycle arrest and apopt ...... sed by a tumorigenic mutation.
@nl
prefLabel
G1 cell cycle arrest and apopt ...... sed by a tumorigenic mutation.
@ast
G1 cell cycle arrest and apopt ...... sed by a tumorigenic mutation.
@en
G1 cell cycle arrest and apopt ...... sed by a tumorigenic mutation.
@nl
P2093
P2860
P356
P1476
G1 cell cycle arrest and apopt ...... sed by a tumorigenic mutation.
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.4.1427
P407
P577
1999-02-01T00:00:00Z