Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis. - Wikidata - awgldk - TriplyDB

Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis.

Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis.

http://www.wikidata.org/entity/Q35005784

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Framework for interpretation of trypsin-antitrypsin imbalance and genetic heterogeneity in pancreatitis Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis Beneficial effects of trypsin inhibitors derived from a spider venom peptide in L-arginine-induced severe acute pancreatitis in mice RAB26 coordinates lysosome traffic and mitochondrial localization.Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death Advances in acute and chronic pancreatitis: from development to inflammation and repair.Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets Endoplasmic reticulum stress is chronically activated in chronic pancreatitis Risk factors for pancreatic cancer: underlying mechanisms and potential targets.Prediction of the severity of acute pancreatitis on admission by urinary trypsinogen activation peptide: a meta-analysis.Redox signaling in acute pancreatitis.Autophagy and pancreatitis Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP.Isolation and culture of mouse primary pancreatic acinar cells Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice.Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in mice.New insights into the pathogenesis of pancreatitis.Molecular mechanisms of pancreatic injury.Animal models for investigating chronic pancreatitis.Role of Intrapancreatic SPINK1/Spink3 Expression in the Development of Pancreatitis Pathogenic mechanisms of acute pancreatitis.The role of protein synthesis and digestive enzymes in acinar cell injury.A review of animal models of nonneoplastic pancreatic diseases.Role of pancreatic fat in the outcomes of pancreatitis.Pathophysiological mechanisms in acute pancreatitis: Current understanding.Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth.Immunopathogenesis of pancreatitis.Pancreatic fistulae secondary to trypsinogen activation by Pseudomonas aeruginosa infection after pancreatoduodenectomy.Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis.Release of Cathepsin B in Cytosol Causes Cell Death in Acute Pancreatitis.Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis.Trypsinogen activation in acute and chronic pancreatitis: is it a prerequisite?Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models.ADP-ribosylation factor 1 protein regulates trypsinogen activation via organellar trafficking of procathepsin B protein and autophagic maturation in acute pancreatitis.Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice.Digesting new information about the role of trypsin in pancreatitis.The apoptosis of peripheral blood lymphocytes promoted by hyperbaric oxygen treatment contributes to attenuate the severity of early stage acute pancreatitis in rats.

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P2860

Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis.

http://www.wikidata.org/entity/Q35005784

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Intracellular activation of tr ...... but not chronic pancreatitis.

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Intracellular activation of tr ...... but not chronic pancreatitis.

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Intracellular activation of tr ...... but not chronic pancreatitis.

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Intracellular activation of tr ...... but not chronic pancreatitis.

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Baoan Ji

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Craig D Logsdon

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Daniel S Longnecker

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Jaroslaw Daniluk

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Jun Chu

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Lilian Tsou

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Sebastian Gaiser

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Woojin Lee

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Yan Liu

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P2860

Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis

Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis

CCK independently activates intracellular trypsinogen and NF-kappaB in rat pancreatic acinar cells.

Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen.

Progression of alcoholic acute to chronic pancreatitis

Clinical practice. Acute pancreatitis.

Rapid generation of inducible mouse mutants

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