TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. - Wikidata - awgldk - TriplyDB

TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.

TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.

http://www.wikidata.org/entity/Q35009467

about

Regulation of Bim in Health and Disease Depolarization Controls TRAIL-Sensitization and Tumor-Selective Killing of Cancer Cells: Crosstalk with ROS The Janus Face of Death Receptor Signaling during Tumor Immunoediting A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells Modeling the TNFα-induced apoptosis pathway in hepatocytes.Cyclic AMP-guanine exchange factor activation inhibits JNK-dependent lipopolysaccharide-induced apoptosis in rat hepatocytes.Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase.TRAIL in cancer therapy: present and future challenges.Dacarbazine and the agonistic TRAIL receptor-2 antibody lexatumumab induce synergistic anticancer effects in melanoma.Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway.Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels.Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease.Characterization of the role of tumor necrosis factor apoptosis inducing ligand (TRAIL) in spermatogenesis through the evaluation of trail gene-deficient mice.Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage.PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.A review of the mammalian unfolded protein response.Bim and Bmf in tissue homeostasis and malignant disease.The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo.NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms.Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation.A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist.Cellular and molecular mechanisms of liver injury.Hepatitis C virus infection and apoptosis TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance.Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.To kill a tumor cell: the potential of proapoptotic receptor agonists Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta (TGFbeta)-induced Bim transcription in hepatic cells Caspases and kinases in a death grip.Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria.Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family.RIPK1 protects hepatocytes from death in Fas-induced hepatitis.

P2860

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P2860

TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.

http://www.wikidata.org/entity/Q35009467

description

2006 nî lūn-bûn

@nan

2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

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2006年論文

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2006年論文

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2006年論文

@zh-hk

2006年論文

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2006年論文

@zh-tw

2006年论文

@wuu

name

TRAIL receptor-mediated JNK ac ...... ed liver damage and lethality.

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TRAIL receptor-mediated JNK ac ...... ed liver damage and lethality.

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type

label

TRAIL receptor-mediated JNK ac ...... ed liver damage and lethality.

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TRAIL receptor-mediated JNK ac ...... ed liver damage and lethality.

@en

prefLabel

TRAIL receptor-mediated JNK ac ...... ed liver damage and lethality.

@ast

TRAIL receptor-mediated JNK ac ...... ed liver damage and lethality.

@en

P1433

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P1433

Journal of Clinical Investigation

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TRAIL receptor-mediated JNK ac ...... ted liver damage and lethality

@en

P2093

Adrian Keogh

http://www.w3.org/2001/XMLSchema#string

Corinne Schaer

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Daniela Kassahn

http://www.w3.org/2001/XMLSchema#string

Deborah Stroka

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Nadia Corazza

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Ralph Torgler

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Sabine Jakob

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Steffen Frese

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Thomas Brunner

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P2860

The Hallmarks of Cancer

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

Proliferation, cell cycle and apoptosis in cancer

Modulation of life and death by the TNF receptor superfamily

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

Safety and antitumor activity of recombinant soluble Apo2 ligand.

P304

2493-2499

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10.1172/JCI27726

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9

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116

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Pascal Schneider

Christoph Mueller

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2006-09-01T00:00:00Z

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6835333

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16955144

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phosphorylation

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1555640

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