Copper and zinc binding to amyloid-beta: coordination, dynamics, aggregation, reactivity and metal-ion transfer.
about
NMR solution structure of rat aβ(1-16): toward understanding the mechanism of rats' resistance to Alzheimer's diseasePhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)The effect of zinc and the role of p53 in copper-induced cellular stress responses.Effect of metals on kinetic pathways of amyloid-β aggregationA prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.Zinc and human health: an update.Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's DiseaseDesign of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β SpeciesMolecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy.Alzheimer's disease & metals: therapeutic opportunities.Effect of C-terminal residues of Aβ on copper binding affinity, structural conversion and aggregation.Substantial contribution of the two imidazole rings of the His13-His14 dyad to Cu(II) binding in amyloid-β(1-16) at physiological pH and its significance.Intrinsic determinants of Aβ(12-24) pH-dependent self-assembly revealed by combined computational and experimental studies.Misfolded proteins in Alzheimer's disease and type II diabetes.Reactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species.Nanoprobing of the effect of Cu(2+) cations on misfolding, interaction and aggregation of amyloid β peptide.Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β speciesInteraction between amyloid-β peptide and heme probed by electrochemistry and atomic force microscopy.Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer's Disease and Nondemented Elderly Controls.Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species.Capturing a reactive state of amyloid aggregates: NMR-based characterization of copper-bound Alzheimer disease amyloid β-fibrils in a redox cycle.The link between iron, metabolic syndrome, and Alzheimer's disease.Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity.Metal ions, Alzheimer's disease and chelation therapy.Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Selenoprotein P and selenoprotein M block Zn2+ -mediated Aβ42 aggregation and toxicity.Beta-amyloid oligomers: recent developments.Dynamics of protein folding and cofactor binding monitored by single-molecule force spectroscopy.Histidine availability is decisive in ROS-mediated cytotoxicity of copper complexes of Aβ1-16 peptide.Two macrocyclic polyamines as modulators of metal-mediated Aβ40 aggregation.Similarities and differences of copper and zinc cations binding to biologically relevant peptides studied by vibrational spectroscopies.Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease.Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.The effect of Cu(2+) and Zn(2+) on the Aβ42 peptide aggregation and cellular toxicityDivalent copper ion bound amyloid-β(40) and amyloid-β(42) alloforms are less preferred than divalent zinc ion bound amyloid-β(40) and amyloid-β(42) alloforms.Amyloid plaques beyond Aβ: a survey of the diverse modulators of amyloid aggregation.
P2860
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P2860
Copper and zinc binding to amyloid-beta: coordination, dynamics, aggregation, reactivity and metal-ion transfer.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Copper and zinc binding to amy ...... tivity and metal-ion transfer.
@ast
Copper and zinc binding to amy ...... tivity and metal-ion transfer.
@en
type
label
Copper and zinc binding to amy ...... tivity and metal-ion transfer.
@ast
Copper and zinc binding to amy ...... tivity and metal-ion transfer.
@en
prefLabel
Copper and zinc binding to amy ...... tivity and metal-ion transfer.
@ast
Copper and zinc binding to amy ...... tivity and metal-ion transfer.
@en
P356
P1433
P1476
Copper and zinc binding to amy ...... tivity and metal-ion transfer.
@en
P2093
Peter Faller
P304
P356
10.1002/CBIC.200900321
P577
2009-12-01T00:00:00Z