Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.
about
A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms.Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer's disease.Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac SulfideMapping the interactions between the Alzheimer's Aβ-peptide and human serum albumin beyond domain resolution.A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimer's disease.Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.Small amphipathic molecules modulate secondary structure and amyloid fibril-forming kinetics of Alzheimer disease peptide Aβ(1-42).Alzheimer's disease: which type of amyloid-preventing drug agents to employ?Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's DiseaseSynthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β SpeciesMolecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy.Alzheimer's disease & metals: therapeutic opportunities.A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease.Targeting Metal-Aβ Aggregates with Bifunctional Radioligand [(11)C]L2-b and a Fluorine-18 Analogue [(18)F]FL2-bNew multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol.Misfolded proteins in Alzheimer's disease and type II diabetes.Tools of the trade: investigations into design strategies of small molecules to target components in Alzheimer's disease.Inhibitory effects of magnolol and honokiol on human calcitonin aggregation.Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.Rationally Designed CeNP@MnMoS4 Core-Shell Nanoparticles for Modulating Multiple Facets of Alzheimer's Disease.Side-chain dynamics reveals transient association of Aβ(1-40) monomers with amyloid fibers.Reactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species.Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer's disease.Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β speciesAmyloid-β-neuropeptide interactions assessed by ion mobility-mass spectrometry.Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species.Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's diseaseMetallostasis and amyloid β-degrading enzymes.Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders.Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice.Tomographic docking suggests the mechanism of auxin receptor TIR1 selectivity.Ultraviolet light triggers the conversion of Cu2+-bound Aβ42 aggregates into cytotoxic species in a copper chelation-independent manner.Small bifunctional chelators that do not disaggregate amyloid β fibrils exhibit reduced cellular toxicity.3-Hydroxy-4-pyridinone derivatives as metal ion and amyloid binding agents.The effect of Cu(2+) and Zn(2+) on the Aβ42 peptide aggregation and cellular toxicitySalvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer's disease.Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology.Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.
P2860
Q27336229-7CA495E0-53D2-494F-95E4-907E3D573099Q28821943-514FAA7F-46D3-40F5-AE43-0EFDB9C55E0AQ30379691-58E7F5FC-F9C8-489F-9429-7BE0E15B111FQ30671407-8B8A2265-4728-45A9-9820-2599D91A9C4EQ33863553-8EE9317A-3743-4375-99A5-93168257301DQ33894829-0E0DA4CA-FB38-4EF9-B023-B622B837AC33Q34213669-9A786F12-0DE1-486E-815D-14E329D9BA4FQ34330351-936A38DF-D035-47A8-99B8-5393CA104336Q34416770-42DD8503-6F79-49BD-BB7C-69C4C06086E0Q34441109-8040232C-E957-4F10-A786-6C6C5518B7CEQ34779975-FCDA1F23-5835-4A3B-B945-BA7F4128900EQ34919551-7C7C6B0B-F73D-4FA1-9D5C-69E6089B440CQ35064636-0D0DAAF9-4A3F-4B63-B083-40A4774A6056Q35087838-B042C34B-635B-44F9-AB34-E7512C7EAF1AQ35199867-9FFB9CA9-886A-4606-9E83-D47301C1206CQ35535599-39FDE424-90D1-4816-A8BE-468181E3B788Q35577737-4F340659-1208-485E-BF27-A07767C15BEBQ36012254-3F6C1ABC-D23E-4BA1-8352-BA29D4F3C288Q36047382-3CCB0776-8336-4E7C-A8BB-D23A27697EF5Q36094624-9CB3D294-008D-41B0-B145-DAE2098EA7DAQ36502645-CCBAE1E1-183B-4A96-B62B-CE8D9737B713Q36598558-9225CF00-F7BB-48DB-A0A9-796112B729C8Q36615734-33A82E84-4020-44F0-B42A-5BA19A71BE16Q36673287-48CC2635-E5C9-437F-BBD6-8B8D9527600BQ36879051-7EA7FC46-1F63-4993-BCAB-C87C856CEACBQ37222626-B5AECF0B-133C-4214-A1D9-0CF49AD4E966Q37590895-365591CF-42F9-438C-9A8F-B6294B3BACE4Q38029514-80CD0DAB-BFF1-4D41-BD4C-D560FD49AF6FQ38066606-1E2C47C1-01BB-44B0-8869-FB5758726654Q38199617-467DA462-4D53-4130-A625-1ACEE5A14932Q38237519-5970F2FC-EB0F-4CA0-A045-9A821AD087ECQ38765764-DF063F73-B790-4567-8F1B-00B702FC4CC3Q38800365-7046B8E5-3BA9-4837-9DEE-1D9654E5F883Q38836859-97281955-6C05-443D-9317-13DC48113B2EQ38946116-7FF289F7-B342-408E-9B4B-9D1804E4901CQ39100957-332C9C7F-B15F-47D9-BBF3-FFEBD6E03A16Q39101514-DE91190C-5F61-4DE3-BD1F-C914A7B3A048Q39148094-21E7AF3D-D712-4B5D-8519-AD0FEB2CAC7DQ39322110-62A6DC16-1783-4E30-9A51-41A2395CA987Q39466684-85798D2C-1427-4604-B5E8-A807048F0551
P2860
Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Design of small molecules that ...... aggregation and neurotoxicity.
@ast
Design of small molecules that ...... aggregation and neurotoxicity.
@en
Design of small molecules that ...... aggregation and neurotoxicity.
@nl
type
label
Design of small molecules that ...... aggregation and neurotoxicity.
@ast
Design of small molecules that ...... aggregation and neurotoxicity.
@en
Design of small molecules that ...... aggregation and neurotoxicity.
@nl
prefLabel
Design of small molecules that ...... aggregation and neurotoxicity.
@ast
Design of small molecules that ...... aggregation and neurotoxicity.
@en
Design of small molecules that ...... aggregation and neurotoxicity.
@nl
P2093
P2860
P356
P1476
Design of small molecules that ...... aggregation and neurotoxicity
@en
P2093
Joseph J Braymer
Jung-Suk Choi
Mi Hee Lim
Ravi P R Nanga
P2860
P304
21990-21995
P356
10.1073/PNAS.1006091107
P407
P577
2010-12-03T00:00:00Z