about
Anti-inflammatory effects of flavonoids [etc.]Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxideArginine deprivation therapy for malignant melanomaDesign and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthaseInhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: implication in inducible nitric oxide synthase expressionNew insights into male (in)fertility: the importance of NOStructure-Based Design and Synthesis of N ω -Nitro- l -Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural WaterMinimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase InhibitorsUnexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal ModelExploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine DerivativesStructure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide SynthaseSelective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics SimulationsPotent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of MelanomaNitric Oxide Synthase Inhibitors That Interact with Both Heme Propionate and Tetrahydrobiopterin Show High Isoform SelectivityInhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and DevelopmentFarnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulationMathematical and computational models of oxidative and nitrosative stressSmall-molecule inhibitors of protein-protein interactions: progressing towards the dreamRole of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptideA nitric oxide donor reduces brain injury and enhances recovery of cerebral blood flow after hypoxia-ischemia in the newborn rat.Regulation of interdomain electron transfer in the NOS output state for NO productionPulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase.Serine racemase deletion protects against cerebral ischemia and excitotoxicity.Role of an isoform-specific substrate access channel residue in CO ligand accessibilities of neuronal and inducible nitric oxide synthase isoforms.Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.CD36 participates in PrP(106-126)-induced activation of microglia.Bioavailability and molecular activities of anthocyanins as modulators of endothelial functionMechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions.Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.Ab initio QM/MM free-energy studies of arginine deiminase catalysis: the protonation state of the Cys nucleophileSymmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthaseAssessment of the effect of diode laser therapy on incisional wound healing and expression of iNOS and eNOS on rat oral tissueStructure-based design of bacterial nitric oxide synthase inhibitors.JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages.Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component?Mechanistic studies of inactivation of inducible nitric oxide synthase by amidinesInhibition of classical PKC isoenzymes downregulates STAT1 activation and iNOS expression in LPS-treated murine J774 macrophages.Nitric oxide signalling with a special focus on lipid-derived mediators.Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid.Protein-protein interactions as drug targets.
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Blocking NO synthesis: how, where and why?
@ast
Blocking NO synthesis: how, where and why?
@en
type
label
Blocking NO synthesis: how, where and why?
@ast
Blocking NO synthesis: how, where and why?
@en
prefLabel
Blocking NO synthesis: how, where and why?
@ast
Blocking NO synthesis: how, where and why?
@en
P356
P1476
Blocking NO synthesis: how, where and why?
@en
P2093
James Leiper
Patrick Vallance
P2888
P304
P356
10.1038/NRD960
P577
2002-12-01T00:00:00Z