Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo - Wikidata - awgldk - TriplyDB

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

http://www.wikidata.org/entity/Q35023290

about

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE A capillary electrophoresis method for evaluation of Abeta proteolysis in vitro Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease Molecular basis for the thiol sensitivity of insulin-degrading enzyme Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease Identification of the allosteric regulatory site of insulysin Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme Anion Activation Site of Insulin-degrading Enzyme Yeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes.Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme.Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis Ageing increases vulnerability to aβ42 toxicity in Drosophila Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.Hippocampal gene expression meta-analysis identifies aging and age-associated spatial learning impairment (ASLI) genes and pathways.Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease.Cloning, expression and characterization of insulin-degrading enzyme from tomato (Solanum lycopersicum).Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1 Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties Alteration of Aβ metabolism-related molecules in predementia induced by AlCl3 and D-galactose Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.Environmental experience modulates ischemia-induced amyloidogenesis and enhances functional recovery.Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early Intervention Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain.Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides.Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches.Cell-permeable, small-molecule activators of the insulin-degrading enzyme.Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells.Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective

P2860

Q24300365-C4A6B362-7689-462C-9E4B-EE1C0E646DB2 Q24307623-5DF1A8F8-3FD7-44E2-82F1-0CBA85D070B9 Q24317274-B1D7167E-4DC0-448C-8D99-DDCF9716744C Q24620093-CA52800D-7C7E-4672-8FE3-3903FB1F2C23 Q24654247-3A8772EB-0EDA-44AE-9D58-7F86BE78A901 Q24657471-53C62B55-F1EA-4E76-8FB8-BD268FD4A35A Q26773657-DDD964CB-92F7-48E8-B359-3EEFB11EEB81 Q27335211-62CDFA01-DB37-4B0E-80AF-5D80D3535794 Q27654373-9FA8A9F0-6AFB-4BF9-AE2E-91B519C591A5 Q27675355-6052A151-D926-46ED-8839-0DA8E30F3417 Q27931965-45792237-F365-45B1-82AA-126EA5B6C413 Q27932546-76925855-3399-4096-A387-7EAA4D41425E Q28284636-AA74D7BE-460A-4DDD-B470-655C84F93AE5 Q28391254-0498340C-4C13-43EB-A76C-2B0D91ED21F7 Q28567783-1C03B309-D9BF-4DBC-A9BA-D33F37284BF2 Q28570444-0A7CFF78-77F3-4B01-99D5-D37D9712D244 Q28574836-8BC62851-40A5-4F6D-BE90-C72D8E2BD205 Q28727201-AF13F7C8-66E4-4186-AB42-AABE65C70E22 Q30833707-E1B3A5E3-F149-4018-9272-1AC3D82A0B79 Q31123604-40D5E877-40DC-4CD5-96FE-EC738CAA703E Q33291757-840888A5-EA1F-483D-AA1B-3089B14A446F Q33311567-FF1A2248-3362-435A-879D-25ED1FEF33DC Q33362745-75938ED6-4185-493A-ADEC-B472C6B498F8 Q33526360-CABE8F1D-896A-4E70-994B-4A336ACCB629 Q33543086-330FDBC2-9A84-459A-9872-898C677A8118 Q33617218-0497BF1C-920D-42A2-BC70-7F982C0E7C1D Q33637336-36149CA5-972E-4A97-9F31-A46B99E706F2 Q33687072-B9BA2136-885F-4EDB-9EF6-19900A02093E Q33766789-D71A7864-4A98-4353-AEB8-F0C1B947A1B0 Q33838291-C57C796D-22F8-4BCF-A075-580D05FC4CCD Q34130147-6E4B6076-8A49-4977-B274-CF36540453AB Q34199931-BCE1A1FA-D1D0-455A-AEB2-798E0C65E9FB Q34268925-F7B3E51C-468E-454C-9BC6-A5B65E1487BE Q34312807-A2EFDC8C-A192-43B4-A3B7-8146907B0FE7 Q34319474-2CEF630A-A31F-4B2B-B36B-FE5085D23C89 Q34450404-D4AE57CC-160F-402C-9A51-F750F94D8700 Q34477381-4678C6F4-DB98-4A9B-A712-4789B4C37A19 Q34485889-69320022-23BF-4072-9929-F2D4E60EDA40 Q34643575-C97F3960-1932-4387-929B-DB7F40C54E27 Q34657827-F40EF106-F6FF-49A7-A757-899CF2ABE90C

P2860

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

http://www.wikidata.org/entity/Q35023290

description

2003 nî lūn-bûn

@nan

2003 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Amyloid-beta peptide levels in ...... ulysin activity levels in vivo

@ast

Amyloid-beta peptide levels in ...... ulysin activity levels in vivo

@en

type

label

Amyloid-beta peptide levels in ...... ulysin activity levels in vivo

@ast

Amyloid-beta peptide levels in ...... ulysin activity levels in vivo

@en

prefLabel

Amyloid-beta peptide levels in ...... ulysin activity levels in vivo

@ast

Amyloid-beta peptide levels in ...... ulysin activity levels in vivo

@en

P1433

Q35023290-B9B8C4D6-97CA-477A-A651-16DC840AF721

P1476

Q35023290-FA1A388F-AE9B-4B77-AD0F-663A466780AA

P2093

Q35023290-008E97B7-FBF3-43BE-A28C-AE4AAE37D6B0

Q35023290-12894701-A0B1-4673-9286-822C7FB6FA3F

Q35023290-25C33B95-E925-4D91-8D32-ACE940371AE9

Q35023290-307BF1A6-549C-43AF-A1FC-54B8D4C995D8

Q35023290-8717BF6C-A47B-43E5-A3D5-C018B188B9A5

Q35023290-D0FFC3BC-2ACF-469B-BFC6-03A616AECBB5

Q35023290-FD6AE896-4D8E-4F3E-B6B9-F1EEF527F2EC

P2860

Q35023290-12009A8F-81F9-4FA8-8AC3-1C1C09A6645C

Q35023290-126F7FB3-CA89-4316-AE75-71BFD236E688

Q35023290-136A94BC-9706-41C3-A1A1-BFA3679C0A28

Q35023290-16A0A14C-B1DF-430B-A9BA-EFB989AC62F8

Q35023290-20986878-8523-4DD6-A7F0-7978BC5C69E9

Q35023290-237DBDDB-F01B-48CA-AE57-05495A80BE19

Q35023290-25DFB591-0DD0-4AFE-BCF5-722412A0BFE6

Q35023290-311951FE-2FD6-43A0-9990-BDEB196400DA

Q35023290-317FE82F-06B3-43C0-B3F3-0360FCF933FC

Q35023290-4909B1B7-246E-4423-8FDE-DFE65950F92E

P304

Q35023290-4066CF2F-9566-4F22-9201-E647DA2792CF

P31

Q35023290-4F1857C0-0585-463E-A0F4-BB39C62FE35B

P356

Q35023290-8F301FBD-1600-4717-BBF0-FC21BCC53801

P407

Q35023290-F2788DCA-5CDC-460E-BD35-F519CACEE842

P433

Q35023290-C245F2DF-4359-43C0-8F53-E7E02E260F22

P478

Q35023290-4B8AFA93-A761-451B-AC5D-4BB705AB0C56

P50

Q35023290-131C6009-5470-4007-BBAE-5E797035C438

P577

Q35023290-67B594A4-F3DA-4668-A466-CB0596A1E584

P5875

Q35023290-2EDB13F5-F8C7-4034-9F35-4C46631D1604

P698

Q35023290-64D8BE3C-9A88-4CFC-896E-D6B123D1F633

P932

Q35023290-C29FDD9E-D795-48CA-9BAD-15465D6C9F14

P356

PNAS.1031520100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Amyloid-beta peptide levels in ...... ulysin activity levels in vivo

@en

P2093

Bonnie C Miller

http://www.w3.org/2001/XMLSchema#string

Christopher B Eckman

http://www.w3.org/2001/XMLSchema#string

Dwain L Thiele

http://www.w3.org/2001/XMLSchema#string

Elizabeth A Eckman

http://www.w3.org/2001/XMLSchema#string

K Martin Chow

http://www.w3.org/2001/XMLSchema#string

Louis B Hersh

http://www.w3.org/2001/XMLSchema#string

Nicole Dobbs

http://www.w3.org/2001/XMLSchema#string

P2860

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

P304

6221-6226

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1031520100

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

100

http://www.w3.org/2001/XMLSchema#string

P50

Kumar Sambamurti

P577

2003-05-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

10772234

http://www.w3.org/2001/XMLSchema#string

P698

12732730

http://www.w3.org/2001/XMLSchema#string

P932

156353

http://www.w3.org/2001/XMLSchema#string