Evidence for an intermediate with a single-strand break in the reaction catalyzed by the DNA untwisting enzyme.
about
Biochemical and biophysical analyses of recombinant forms of human topoisomerase I3'-modified oligonucleotides by reverse DNA synthesis.DNA duplexes containing 3'-deoxynucleotides as substrates for DNA topoisomerase I cleavage and ligation.The bioavailability of oral GI147211 (GG211), a new topoisomerase I inhibitorPeptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.Postreplication repair in mammalian cells after ultraviolet irradiation: a modelphiX174 cistron A protein is a multifunctional enzyme in DNA replicationRenaturation of complementary single-stranded DNA circles: complete rewinding facilitated by the DNA untwisting enzyme.Strand breakage by the DNA untwisting enzyme results in covalent attachment of the enzyme to DNATopoisomerase I is preferentially associated with normal SV40 replicative intermediates, but is associated with both replicating and nonreplicating SV40 DNAs which are deficient in histones.Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA.DNA breakage and closure by rat liver type 1 topoisomerase: separation of the half-reactions by using a single-stranded DNA substrate.Ethidium bromide-mediated renaturation of denatured closed circular DNAs. The nature of denaturation-resistant fractions of bacteriophage PM2 closed circular DNABreakage of single-stranded DNA by rat liver nicking-closing enzyme with the formation of a DNA-enzyme complex.Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.Interaction of the DNA untwisting enzyme with the SV40 nucleoprotein complex.Topoisomerase I inhibitors: the relevance of prolonged exposure for present clinical development.Late replicative intermediates are accumulated during simian virus 40 DNA replication in vivo and in vitroTopoisomerase I-mediated integration of hepadnavirus DNA in vitro.Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase IMapping in vivo topoisomerase I sites on simian virus 40 DNA: asymmetric distribution of sites on replicating moleculesTopoisomerase I sites cluster asymmetrically at the ends of the simian virus 40 core origin of replication.Nicking-closing enzyme assembles nucleosome-like structures in vitroAdenovirus infection elevates levels of cellular topoisomerase I.DNA-relaxing enzyme from Micrococcus luteus.Cleavage and circularization of single-stranded DNA: a novel enzymatic activity of phi X174 A* protein.DNA topoisomerase from Agrobacterium tumefaciens: purification and catalytic properties.Preferential binding of human topoisomerase I to superhelical DNA.Reverse gyrase binding to DNA alters the double helix structure and produces single-strand cleavage in the absence of ATP.Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane.Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani.Current perspectives on camptothecins in cancer treatment
P2860
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P2860
Evidence for an intermediate with a single-strand break in the reaction catalyzed by the DNA untwisting enzyme.
description
1976 nî lūn-bûn
@nan
1976 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1976 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1976年の論文
@ja
1976年論文
@yue
1976年論文
@zh-hant
1976年論文
@zh-hk
1976年論文
@zh-mo
1976年論文
@zh-tw
1976年论文
@wuu
name
Evidence for an intermediate w ...... by the DNA untwisting enzyme.
@ast
Evidence for an intermediate w ...... by the DNA untwisting enzyme.
@en
type
label
Evidence for an intermediate w ...... by the DNA untwisting enzyme.
@ast
Evidence for an intermediate w ...... by the DNA untwisting enzyme.
@en
prefLabel
Evidence for an intermediate w ...... by the DNA untwisting enzyme.
@ast
Evidence for an intermediate w ...... by the DNA untwisting enzyme.
@en
P2860
P356
P1476
Evidence for an intermediate w ...... by the DNA untwisting enzyme.
@en
P2093
Champoux JJ
P2860
P304
P356
10.1073/PNAS.73.10.3488
P407
P577
1976-10-01T00:00:00Z