The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
about
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanismFemale lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathwayHypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau proteinUPR-induced resistance to etoposide is downstream of PERK and independent of changes in topoisomerase IIα levelsHypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brainMolecular pathology and CXCR4 expression in surgically excised retinal hemangioblastomas associated with von Hippel-Lindau disease.Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression.Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration.The von hippel-lindau protein suppresses androgen receptor activity.The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis.Clinicopathologic significance of HIF-1α, CXCR4, and VEGF expression in colon cancer.Dual inhibition of plasminogen kringle 5 on angiogenesis and chemotaxis suppresses tumor metastasis by targeting HIF-1α pathway.Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancerRegulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis.pVHL acts as a downstream target of E2F1 to suppress E2F1 activity.Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development.HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature.Oncogenic aberrations of cullin-dependent ubiquitin ligases.Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells.Expression of hypoxia-inducible carbonic anhydrases in brain tumors.Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha.Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection.Anterior gradient 2 is a binding stabilizer of hypoxia inducible factor-1α that enhances CoCl2 -induced doxorubicin resistance in breast cancer cells.Cellular response to tissue hypoxia and its involvement in disease progression.Molecularly targeted therapy in renal cell carcinoma.Regulation of the chemokine receptor CXCR4 by hypoxia.Redox regulation of the hypoxia-inducible factor.The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancersTemporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lungVon Hippel-Lindau disease: an evaluation of natural history and functional disabilityAberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cellsHIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity.Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic UseAdvances in the systemic treatment of cutaneous sarcomas.Cullin-RING Ligases as attractive anti-cancer targets.Renal cell carcinoma development and miRNAs: a possible link to the EGFR pathway.Human activated macrophages and hypoxia: a comprehensive review of the literature.
P2860
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P2860
The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
name
The von Hippel-Lindau tumor su ...... tion, and cancer pathogenesis.
@ast
The von Hippel-Lindau tumor su ...... tion, and cancer pathogenesis.
@en
type
label
The von Hippel-Lindau tumor su ...... tion, and cancer pathogenesis.
@ast
The von Hippel-Lindau tumor su ...... tion, and cancer pathogenesis.
@en
prefLabel
The von Hippel-Lindau tumor su ...... tion, and cancer pathogenesis.
@ast
The von Hippel-Lindau tumor su ...... tion, and cancer pathogenesis.
@en
P1476
The von Hippel-Lindau tumor su ...... ation, and cancer pathogenesis
@en
P2093
Christopher William Pugh
P356
10.1016/S1044-579X(02)00103-7
P577
2003-02-01T00:00:00Z