Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
about
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNABypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design.Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.Mechanism of quinolone action and resistance.Functional determinants of gate-DNA selection and cleavage by bacterial type II topoisomerases.Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance.Calcium-driven DNA synthesis by a high-fidelity DNA polymerase.Synthesis and investigation of binding interactions of 1,4-benzoxazine derivatives on topoisomerase IV in Acinetobacter baumannii.DNA Topoisomerases as Targets for Antibacterial Agents.Topoisomerases as anticancer targets.A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
P2860
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P2860
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
@ast
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
@en
type
label
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
@ast
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
@en
prefLabel
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
@ast
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
@en
P2093
P2860
P356
P1476
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
@en
P2093
Alex B Burgin
Anthony Maxwell
Grace F Liou
Keir C Neuman
Lesley A Mitchenall
Neil Osheroff
Steven L Pitts
P2860
P304
P356
10.1093/NAR/GKR018
P407
P577
2011-02-07T00:00:00Z