G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. - Wikidata - awgldk - TriplyDB

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

http://www.wikidata.org/entity/Q35041039

about

GRK2: multiple roles beyond G protein-coupled receptor desensitization G-protein-coupled receptor kinase 2 and endothelial dysfunction: molecular insights and pathophysiological mechanisms GRK2 in the heart: a GPCR kinase and beyond Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes."Freeze, Don't Move": How to Arrest a Suspect in Heart Failure - A Review on Available GRK2 Inhibitors Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart.Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy.Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.The evolving impact of g protein-coupled receptor kinases in cardiac health and disease Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.Direct Evidence that Myocardial Insulin Resistance following Myocardial Ischemia Contributes to Post-Ischemic Heart Failure Sustained βAR Stimulation Mediates Cardiac Insulin Resistance in a PKA-Dependent Manner.IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases.Adrenergic receptors and metabolism: role in development of cardiovascular disease Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction.Adrenergic signaling and oxidative stress: a role for sirtuins?Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology β-Adrenergic Receptor and Insulin Resistance in the Heart.G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms.Molecular aspects of the cardioprotective effect of exercise in the elderly.Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy Effects of exercise training on cardiovascular adrenergic system.Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling.G protein-coupled receptor kinase 2 promotes cardiac hypertrophy Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2.Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy.Dual role of GRK5 in cancer development and progression.Rays Sting: The Acute Cellular Effects of Ionizing Radiation Exposure.GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease.Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart.GRK2 negatively regulates IGF-1R signaling pathway and cyclins' expression in HepG2 cells.Noncanonical Roles of G Protein-coupled Receptor Kinases in Cardiovascular Signaling.Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors.

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P2860

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

http://www.wikidata.org/entity/Q35041039

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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G protein-coupled receptor kin ...... nce after myocardial ischemia.

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G protein-coupled receptor kin ...... nce after myocardial ischemia.

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Erhe Gao

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Gerald W Dorn

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J Kurt Chuprun

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Jessica I Gold

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Mai Chen

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Nicholas J Otis

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Raymond J Peroutka

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Walter J Koch

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Zhengyu Wei

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P2860

Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts

Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

The failing heart--an engine out of fuel

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.

An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in Patients with Congestive Heart Failure.

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.

Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: a biomarker for left ventricular function.

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