Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol. - Wikidata - awgldk - TriplyDB

Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol.

Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol.

http://www.wikidata.org/entity/Q35042675

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Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?The transmembrane domain of TACE regulates protein ectodomain shedding Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activity.The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability.Acetylcholine and alcohol sensitivity of neuronal nicotinic acetylcholine receptors: mutations in transmembrane domains.Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.Structural basis for alcohol modulation of a pentameric ligand-gated ion channel Tryptophan scanning mutagenesis of the first transmembrane domain of the innexin Shaking-B(Lethal).Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel The TM2 6' position of GABA(A) receptors mediates alcohol inhibition Tryptophan Scanning Reveals Dense Packing of Connexin Transmembrane Domains in Gap Junction Channels Composed of Connexin32 Fourier transform coupled to tryptophan-scanning mutagenesis: lessons from its application to the prediction of secondary structure in the acetylcholine receptor lipid-exposed transmembrane domains.Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors Alcohol related changes in regulation of NMDA receptor functions GABA(A) receptors and alcohol.Ethanol's molecular targets A single channel mutation alters agonist efficacy at 5-HT3A and 5-HT3AB receptors.Acute alcohol action and desensitization of ligand-gated ion channels.Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive alpha1 GABA A receptors.Emerging approaches to probing ion channel structure and function.A structural and functional comparison of gap junction channels composed of connexins and innexins Mechanisms of anabolic androgenic steroid inhibition of mammalian epsilon-subunit-containing GABAA receptors.Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation.Properties of the Mechanosensitive Channel MscS Pore Revealed by Tryptophan Scanning Mutagenesis.Competing presynaptic and postsynaptic effects of ethanol on cerebellar purkinje neurons.Tryptophan-scanning mutagenesis in the alphaM3 transmembrane domain of the muscle-type acetylcholine receptor. A spring model revealed.Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment.Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics.Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis.Distinct molecular basis for differential sensitivity of the serotonin type 3A receptor to ethanol in the absence and presence of agonist.A TM2 residue in the beta1 subunit determines spontaneous opening of homomeric and heteromeric gamma-aminobutyric acid-gated ion channels.Sites of positive allosteric modulation by neurosteroids on ionotropic gamma-aminobutyric acid receptor subunits.Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation.Sites in TM2 and 3 are critical for alcohol-induced conformational changes in GABA receptors.Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors.

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P2860

Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol.

http://www.wikidata.org/entity/Q35042675

description

2000 nî lūn-bûn

@nan

2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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Tryptophan scanning mutagenesi ...... ing and regulation by ethanol.

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Tryptophan scanning mutagenesi ...... ing and regulation by ethanol.

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Tryptophan scanning mutagenesi ...... ing and regulation by ethanol.

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British Journal of Pharmacology

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Tryptophan scanning mutagenesi ...... ing and regulation by ethanol.

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A Lin

http://www.w3.org/2001/XMLSchema#string

J R Trudell

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N L Harrison

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N Nikolaeva

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R A Harris

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S J Mihic

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S Ueno

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P2860

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function

Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer.

Molecular and functional diversity of the expanding GABA-A receptor gene family.

Ethanol actions on multiple ion channels: which are important?

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.

Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.

Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors

Molecular and cellular mechanisms of general anaesthesia.

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296-302

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10.1038/SJ.BJP.0703504

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2

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10991923

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