Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors. - Wikidata - awgldk - TriplyDB

Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors.

Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors.

http://www.wikidata.org/entity/Q48139780

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Alcoholism: A Systems Approach From Molecular Physiology to Addictive Behavior Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?The Role of Multiple Hydrogen-Bonding Groups in Specific Alcohol Binding Sites in Proteins: Insights from Structural Studies of LUSH Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel Molecular mechanism for the dual alcohol modulation of Cys-loop receptors Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors.A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons.Zinc enhances ethanol modulation of the alpha1 glycine receptor.Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.Molecular targets and mechanisms for ethanol action in glycine receptors Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain.A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.Ethanol is a fast channel inhibitor of P2X4 receptors Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.Contributions of conserved residues at the gating interface of glycine receptors.Activated G protein α s subunits increase the ethanol sensitivity of human glycine receptors Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol The basic property of Lys385 is important for potentiation of the human α1 glycine receptor by ethanol.The TM2 6' position of GABA(A) receptors mediates alcohol inhibition Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism.Roles for loop 2 residues of alpha1 glycine receptors in agonist activation.Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor.Ethanol's molecular targets Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites Single-channel analysis of ethanol enhancement of glycine receptor function Zebrafish: a model for the study of addiction genetics Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation.Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.Molecular and genetic determinants of alcohol dependence.Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol.

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P2860

Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors.

http://www.wikidata.org/entity/Q48139780

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年學術文章

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Evidence that ethanol acts on ...... n of alpha1 glycine receptors.

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Evidence that ethanol acts on ...... n of alpha1 glycine receptors.

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Evidence that ethanol acts on ...... n of alpha1 glycine receptors.

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Evidence that ethanol acts on ...... n of alpha1 glycine receptors.

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Evidence that ethanol acts on ...... n of alpha1 glycine receptors.

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Evidence that ethanol acts on ...... n of alpha1 glycine receptors.

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J.1471-4159.2007.04680.X

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Journal of Neurochemistry

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Evidence that ethanol acts on ...... n of alpha1 glycine receptors.

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Daniel K Crawford

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Edward J Bertaccini

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James R Trudell

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Kaixun Li

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Ronald L Alkana

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P2860

A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse

General anaesthetic actions on ligand-gated ion channels

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

Point mutation of glycine receptor alpha 1 subunit in the spasmodic mouse affects agonist responses

Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure.

Unique assignment of inter-subunit association in GABA(A) alpha 1 beta 3 gamma 2 receptors determined by molecular modeling.

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors.

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