Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies.
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The Nuremberg Code subverts human health and safety by requiring animal modelingModifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma SpecificityUse of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations.Predicting in vivo drug interactions from in vitro drug discovery data.Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adultsSex differences in drug disposition.Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactionsHuman pharmacogenomic variations and their implications for antifungal efficacy.Human carbonyl reduction pathways and a strategy for their study in vitro.Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies.Pharmacokinetic drug interactions involving vortioxetine (Lu AA21004), a multimodal antidepressantPharmacogenetics of analgesics: toward the individualization of prescription.Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail.Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine.Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures.Evaluation of the tissue distribution, excretion, and cytochrome P450 induction studies of a potential antitumor agent, TM-2, in animals using LC-MS/MS.Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set.Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.Relative contributions of the major human CYP450 to the metabolism of icotinib and its implication in prediction of drug-drug interaction between icotinib and CYP3A4 inhibitors/inducers using physiologically based pharmacokinetic modeling.Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing.The utility of cold-preserved human hepatocytes in studies on cytochrome P450 induction and hepatic drug transport.Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research.Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes.Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies.Alfentanil-induced miosis clearance as a liver CYP3A4 and 3A5 activity measure in healthy volunteers: improvement of experimental conditions.Characterization of in vitro metabolites of TM-2, a potential antitumor drug, in rat, dog and human liver microsomes using liquid chromatography/tandem mass spectrometry.Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype.Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies.Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes.Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds.An update on metabolism studies using human hepatocytes in primary culture
P2860
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P2860
Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Strategies and molecular probe ...... sm: focus on in vitro studies.
@ast
Strategies and molecular probe ...... sm: focus on in vitro studies.
@en
type
label
Strategies and molecular probe ...... sm: focus on in vitro studies.
@ast
Strategies and molecular probe ...... sm: focus on in vitro studies.
@en
prefLabel
Strategies and molecular probe ...... sm: focus on in vitro studies.
@ast
Strategies and molecular probe ...... sm: focus on in vitro studies.
@en
P1476
Strategies and molecular probe ...... ism: focus on in vitro studies
@en
P2093
José V Castell
M Teresa Donato
P304
P356
10.2165/00003088-200342020-00004
P577
2003-01-01T00:00:00Z
P6179
1027817893