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Molecular basis for interaction of let-7 microRNAs with Lin28Lin28 and let-7 in cell metabolism and cancerMYC and the art of microRNA maintenanceLin28: primal regulator of growth and metabolism in stem cellsAn RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates11q deletion in neuroblastoma: a review of biological and clinical implications.Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities.HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxiaLin28B expression correlates with aggressive clinicopathological characteristics in breast invasive ductal carcinoma.Role of LIN28A in mouse and human trophoblast cell differentiation.Lin28B is a novel prognostic marker in gastric adenocarcinoma.Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.Genomic DNA copy-number alterations of the let-7 family in human cancersLIN28B promotes colon cancer migration and recurrence.Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers.Expression of secretory leukocyte protease inhibitor detected by immunohistochemistry correlating with prognosis and metastasis in colorectal cancer.Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model.Increased expression of Lin28B associates with poor prognosis in patients with oral squamous cell carcinomaMUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLCDown-Regulation of miR-129-5p and the let-7 Family in Neuroendocrine Tumors and Metastases Leads to Up-Regulation of Their Targets Egr1, G3bp1, Hmga2 and Bach1.Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target.Implications of microRNAs in colorectal cancer development, diagnosis, prognosis, and therapeutics.Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.Identification of small molecule inhibitors of Zcchc11 TUTase activity.The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancyLoss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIMAberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancerHigh expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancerOverexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer.Regulation of senescence by microRNA biogenesis factorsLin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancerLin28 regulates the expression of neuropeptide Y receptors and oocyte-specific homeobox genes in mouse embryonic stem cells.Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphomaThe pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis.How does Lin28 let-7 control development and disease?Prognostic and predictive roles of KRAS mutation in colorectal cancer.A LIN28B polymorphism predicts for colon cancer survival.The implications of cancer stem cells for cancer therapy.PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
LIN28B promotes colon cancer progression and metastasis
@ast
LIN28B promotes colon cancer progression and metastasis
@en
type
label
LIN28B promotes colon cancer progression and metastasis
@ast
LIN28B promotes colon cancer progression and metastasis
@en
prefLabel
LIN28B promotes colon cancer progression and metastasis
@ast
LIN28B promotes colon cancer progression and metastasis
@en
P2093
P2860
P1433
P1476
LIN28B promotes colon cancer progression and metastasis
@en
P2093
Anil K Rustgi
Antoni Castells
Antonia R Sepulveda
Catrina E King
Ju-Seog Lee
Miriam Cuatrecasas
P2860
P304
P356
10.1158/0008-5472.CAN-10-4637
P407
P577
2011-04-21T00:00:00Z