DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis. - Wikidata - awgldk - TriplyDB

DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis.

DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis.

http://www.wikidata.org/entity/Q35053069

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Facioscapulohumeral dystrophy: the path to consensus on pathophysiology Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD)Targeting mRNA for the treatment of facioscapulohumeral muscular dystrophy Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation Detecting endogenous retrovirus-driven tissue-specific gene transcription Friends-Enemies: Endogenous Retroviruses Are Major Transcriptional Regulators of Human DNA Generation of novel patient-derived CIC- DUX4 sarcoma xenografts and cell lines.DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1).DUX4 promotes transcription of FRG2 by directly activating its promoter in facioscapulohumeral muscular dystrophy A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy.Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy.Emerging preclinical animal models for FSHD.Facioscapulohumeral muscular dystrophy as a model for epigenetic regulation and disease New bioinformatic tool for quick identification of functionally relevant endogenous retroviral inserts in human genome.DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy Genetic and epigenetic contributors to FSHD.DNA-binding sequence specificity of DUX4.CRISPR/dCas9-mediated Transcriptional Inhibition Ameliorates the Epigenetic Dysregulation at D4Z4 and Represses DUX4-fl in FSH Muscular Dystrophy.DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis Deregulation of DUX4 and ERG in acute lymphoblastic leukemia.Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD).Correlation between low FAT1 expression and early affected muscle in facioscapulohumeral muscular dystrophy.Loss of epigenetic silencing of the DUX4 transcription factor gene in facioscapulohumeral muscular dystrophy.CTRL+INSERT: retrotransposons and their contribution to regulation and innovation of the transcriptome Phylogenetic and chemotypic diversity of Periglandula species in eight new morning glory hosts (Convolvulaceae).Evolution to the rescue: using comparative genomics to understand long non-coding RNAs.Direct interplay between two candidate genes in FSHD muscular dystrophy.Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells.Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells.Conservation and innovation in the DUX4-family gene network.DUX-family transcription factors regulate zygotic genome activation in placental mammals.A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.Transcriptomic pathway analysis of urokinase receptor silenced breast cancer cells: a microarray study.Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons.PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle.Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei.Profiling of Human Molecular Pathways Affected by Retrotransposons at the Level of Regulation by Transcription Factor Proteins.

P2860

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P2860

DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis.

http://www.wikidata.org/entity/Q35053069

description

2013 nî lūn-bûn

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2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

DUX4 binding to retroelements ...... ive in FSHD muscle and testis.

@ast

DUX4 binding to retroelements ...... ive in FSHD muscle and testis.

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type

label

DUX4 binding to retroelements ...... ive in FSHD muscle and testis.

@ast

DUX4 binding to retroelements ...... ive in FSHD muscle and testis.

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prefLabel

DUX4 binding to retroelements ...... ive in FSHD muscle and testis.

@ast

DUX4 binding to retroelements ...... ive in FSHD muscle and testis.

@en

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JOURNAL.PGEN.1003947

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DUX4 binding to retroelements ...... ive in FSHD muscle and testis.

@en

P2093

Bhavatharini Kasinathan

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Janet M Young

http://www.w3.org/2001/XMLSchema#string

Jennifer L Whiddon

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Judit Balog

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Lauren Snider

http://www.w3.org/2001/XMLSchema#string

Linda N Geng

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Rabi Tawil

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Stephen J Tapscott

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P2860

Initial sequencing and analysis of the human genome

Differential expression analysis for sequence count data

Bioconductor: open software development for computational biology and bioinformatics

Intrinsic epigenetic regulation of the D4Z4 macrosatellite repeat in a transgenic mouse model for FSHD

Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene

Repetitive DNA and next-generation sequencing: computational challenges and solutions

Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis

The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein

The origin and behavior of mutable loci in maize.

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

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scholarly article

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10.1371/JOURNAL.PGEN.1003947

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11

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9

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Silvère M van der Maarel

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2013-11-21T00:00:00Z

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258924075

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24278031

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3836709

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