Stabilization of HIV-1 envelope in the CD4-bound conformation through specific cross-linking of a CD4 mimetic
about
MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaquesInterfacial Cavity Filling To Optimize CD4–Mimetic Miniprotein Interactions with HIV-1 Surface GlycoproteinStabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoproteinElicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoproteinAllosteric induction of the CD4-bound conformation of HIV-1 Gp120.Thermosensitive and mucoadhesive pluronic-hydroxypropylmethylcellulose hydrogel containing the mini-CD4 M48U1 is a promising efficient barrier against HIV diffusion through macaque cervicovaginal mucusFusion proteins of HIV-1 envelope glycoprotein gp120 with CD4-induced antibodies showed enhanced binding to CD4 and CD4 binding site antibodies.Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding.Range of CD4-Bound Conformations of HIV-1 gp120, as Defined Using Conditional CD4-Induced Antibodies.M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures.Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design.HIV vaccines: a brief overview.Increased, durable B-cell and ADCC Responses Associated with T-helper Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site.Crosslinking of a CD4 Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques.
P2860
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P2860
Stabilization of HIV-1 envelope in the CD4-bound conformation through specific cross-linking of a CD4 mimetic
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2011 nî lūn-bûn
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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Stabilization of HIV-1 envelop ...... cross-linking of a CD4 mimetic
@ast
Stabilization of HIV-1 envelop ...... cross-linking of a CD4 mimetic
@en
type
label
Stabilization of HIV-1 envelop ...... cross-linking of a CD4 mimetic
@ast
Stabilization of HIV-1 envelop ...... cross-linking of a CD4 mimetic
@en
prefLabel
Stabilization of HIV-1 envelop ...... cross-linking of a CD4 mimetic
@ast
Stabilization of HIV-1 envelop ...... cross-linking of a CD4 mimetic
@en
P2093
P2860
P356
P1476
Stabilization of HIV-1 envelop ...... cross-linking of a CD4 mimetic
@en
P2093
Anthony R Geonnotti
Antu K Dey
Bernadette Heyd
Brian Burke
Elaine Kan
Grégoire Martin
Hocine Madaoui
Indresh K Srivastava
Jeffrey B Ulmer
Loïc Martin
P2860
P304
21706-21716
P356
10.1074/JBC.M111.232272
P407
P577
2011-04-12T00:00:00Z