Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein
about
Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophagesSynthetic Peptides as Protein MimicsScorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineeringMiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaquesStructure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motifMotions and structural variability within toxins: Implication for their use as scaffolds for protein engineeringCombinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope GlycoproteinStructural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1Interfacial Cavity Filling To Optimize CD4–Mimetic Miniprotein Interactions with HIV-1 Surface GlycoproteinHIV-1 gp120 as a therapeutic target: navigating a moving labyrinthConcerted evolution of structure and function in a miniature proteinAntiviral activity of animal venom peptides and related compoundsDesignability of alpha-helical proteinsA naturally occurring non-coding fusion transcript derived from scorpion venom gland: implication for the regulation of scorpion toxin gene expression.Anti-HIV agents targeting the interaction of gp120 with the cellular CD4 receptor.The Ixodes scapularis salivary protein, salp15, prevents the association of HIV-1 gp120 and CD4Characterization of gp120 and its single-chain derivatives, gp120-CD4D12 and gp120-M9: implications for targeting the CD4i epitope in human immunodeficiency virus vaccine design.Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4.Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4.Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.Crosslinked HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaquesRASMOT-3D PRO: a 3D motif search webserver.Combinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1Exceptionally potent and broadly cross-reactive, bispecific multivalent HIV-1 inhibitors based on single human CD4 and antibody domains.Allosteric induction of the CD4-bound conformation of HIV-1 Gp120.Stabilization of HIV-1 envelope in the CD4-bound conformation through specific cross-linking of a CD4 mimeticProtein grafting of an HIV-1-inhibiting epitopeThermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120.Scorpion peptides: potential use for new drug developmentSmall-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.A simple one-step method for the preparation of HIV-1 envelope glycoprotein immunogens based on a CD4 mimic peptide.Turning a scorpion toxin into an antitumor miniproteinPeptide pal9a from the venom of the turrid snail Polystira albida from the Gulf of Mexico: purification, characterization, and comparison with P-conotoxin-like (framework IX) conoidean peptidesExploring the molecular design of protein interaction sites with molecular dynamics simulations and free energy calculationsSmall-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins.Alanine substitutions of noncysteine residues in the cysteine-stabilized alphabeta motif.Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.Driving HIV-1 into a Vulnerable Corner by Taking Advantage of Viral Adaptation and Evolution.
P2860
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P2860
Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Rational engineering of a mini ...... th HIV-1 envelope glycoprotein
@ast
Rational engineering of a mini ...... th HIV-1 envelope glycoprotein
@en
Rational engineering of a mini ...... th HIV-1 envelope glycoprotein
@nl
type
label
Rational engineering of a mini ...... th HIV-1 envelope glycoprotein
@ast
Rational engineering of a mini ...... th HIV-1 envelope glycoprotein
@en
Rational engineering of a mini ...... th HIV-1 envelope glycoprotein
@nl
prefLabel
Rational engineering of a mini ...... th HIV-1 envelope glycoprotein
@ast
Rational engineering of a mini ...... th HIV-1 envelope glycoprotein
@en
Rational engineering of a mini ...... th HIV-1 envelope glycoprotein
@nl
P2093
P2860
P356
P1476
Rational engineering of a mini ...... th HIV-1 envelope glycoprotein
@en
P2093
A Benjouad
C Roumestand
E Drakopoulou
J C Gluckman
J Vizzavona
L Ylisastigui
S Rochette
P2860
P304
P356
10.1073/PNAS.96.23.13091
P407
P577
1999-11-09T00:00:00Z