Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes - Wikidata - awgldk - TriplyDB

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

http://www.wikidata.org/entity/Q35065308

about

Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity Modeling the study of DNA damage responses in mice Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation Rodent models of neuroinflammation for Alzheimer's disease Sources and implications of NADH/NAD(+) redox imbalance in diabetes and its complications Pathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP)The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage.The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.PARP-1 hyperactivation and reciprocal elevations in intracellular Ca2+ during ROS-induced nonapoptotic cell death Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced β-cell damage and diabetes in mice Commonalities of genetic resistance to spontaneous autoimmune and free radical--mediated diabetes.Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia.New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases.Antihyperglycemic potentials of a threatened plant, Helonias dioica: antioxidative stress responses and the signaling cascade.ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion.Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA Neuronal signal transduction pathways: wasteland or the promised land?Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury.Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line.PARP-1 and YY1 are important novel regulators of CXCL12 gene transcription in rat pancreatic beta cells PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia.Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death.Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2.Poly(ADP-ribose) polymerase 1-sirtuin 1 functional interplay regulates LPS-mediated high mobility group box 1 secretion.CXC chemokine ligand 12 protects pancreatic β-cells from necrosis through Akt kinase-mediated modulation of poly(ADP-ribose) polymerase-1 activity.Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion.Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion.Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake.Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus.CD38 autoimmunity: recent advances and relevance to human diabetes.PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice.

P2860

Q26752842-5C00AF84-3134-4EBE-B0A9-8407B9534EC1 Q26773988-0F763D8E-F80A-45BC-A13E-0C615E8CEF2F Q26826949-AA47FEC0-D028-4734-9E06-288B60A36BFE Q26858894-26C33373-6A1C-4ADC-AAE9-8C29DDAC7E43 Q26864804-E8C97998-04B9-4AB3-9B46-B76E7368FF8A Q28076120-D3A918CB-DB44-4E16-A2F2-E091020AAD81 Q28080057-650128FC-8AEF-401C-9716-DCAB23DF08D9 Q28190711-FFAE6EC6-4281-4B8B-937D-D30FD223D8CC Q28343931-3402BDBF-0308-4D0C-9F20-C8B08EEAFC46 Q28508144-892B965A-3183-466E-8A7B-52D5B9155CA8 Q29617672-3863E4C6-2A0F-4CD7-9FF6-86D598961337 Q30640821-868D232F-92CC-4DFC-A65A-63F63DF1F14D Q33598840-1B798759-A1A8-4968-BFEF-FE11D6CD2F7C Q33779682-5584242B-B591-4164-82F4-FB882EAF60F1 Q33845289-AB76B3CA-16E8-4117-9415-CF529C383AFE Q33855851-62954AEF-810A-45D0-94F9-52A845632420 Q33857810-7378BF9C-8632-45A2-9D0C-3F1693FC3A33 Q34017468-71579605-BB18-441F-AE16-60CFFB0C52BC Q34042969-9D559617-0E8F-4849-A1E0-03486D3D6D75 Q34101111-0361630C-B129-4258-87C2-5A8765FFACD4 Q34254806-CF0FE519-E05F-4312-976F-200C0B3D574D Q34357781-81AC8705-38C3-45FC-B011-E805277D7C93 Q34467681-99354F11-6689-46E2-8D09-0A708D43C452 Q34520738-FBFF63FA-7C28-4711-BB3F-CD8DF32C4C71 Q34570024-BA4F30FD-A3C5-4BE4-A49E-9E59AD28AD74 Q34638102-8DC92F71-E1FD-43F2-A2B4-F233BBA247AF Q34651839-6D422D3B-258C-4B92-A0C1-04950BBF2FD4 Q34670090-CB4F9B2F-0EAF-4B2D-AAE3-827EC35BBCE9 Q34730830-A7B3E227-AC19-4FC1-AFC0-72C3544FA58E Q35048713-59C0B64E-BC4C-48DA-8A6B-5DAB793BB0A9 Q35082036-DD1A266E-CCBC-4080-9B3D-B24D84C9F014 Q35131356-49256385-DAC8-48CE-9268-C4BBF43EFA2D Q35192798-2EF166CE-C2C8-40EE-80BF-6D762D4C3787 Q35200250-C415A8FC-C0B8-45BA-8B8F-A17D7E061BE6 Q35492308-AF0DC088-F19D-4D0A-A06C-60AFD53A5AB7 Q35648004-18495283-5347-44BA-8E10-A203E85A1684 Q35885256-6C3A5FA2-8FBA-465B-B1EA-40FAFFD3CD96 Q35903412-A1D50164-E596-4C23-B813-0D1E1092D926 Q35928098-BCCBBF03-E4F5-48DE-A4FB-74E595692665 Q36047526-DAA397D3-97BB-4966-806C-4EA1678C6B6C

P2860

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

http://www.wikidata.org/entity/Q35065308

description

1999 nî lūn-bûn

@nan

1999 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի մարտին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

Poly(ADP-ribose) polymerase-de ...... treptozotocin-induced diabetes

@ast

Poly(ADP-ribose) polymerase-de ...... treptozotocin-induced diabetes

@en

type

label

Poly(ADP-ribose) polymerase-de ...... treptozotocin-induced diabetes

@ast

Poly(ADP-ribose) polymerase-de ...... treptozotocin-induced diabetes

@en

prefLabel

Poly(ADP-ribose) polymerase-de ...... treptozotocin-induced diabetes

@ast

Poly(ADP-ribose) polymerase-de ...... treptozotocin-induced diabetes

@en

P1433

Q35065308-12B08710-1479-4AA2-B1FF-0771F42C3989

P1476

Q35065308-E93B49F5-BC11-4DE0-ACAF-2AB2CAB2A240

P2093

Q35065308-0B838789-2F23-40A6-BF0A-DD2B271E7846

Q35065308-2144C73E-65D3-4C92-82F7-557F9F690BC3

Q35065308-3FDDBFB5-80B2-48DB-94B8-6F8AB6052717

Q35065308-5138E5B4-125C-4DF7-975F-29EE78DC5460

Q35065308-71E94657-FEEA-484E-B4C2-66BBB720B931

Q35065308-C2F3E20B-C3BD-4B9D-8948-46D42449C299

Q35065308-F76499DD-9AFD-49C6-92ED-1F5821268253

Q35065308-FA328E06-02F0-41A2-A4AE-860880A52D9C

P2860

Q35065308-12D70F38-6CCD-4576-866F-2F1D31BFE873

Q35065308-1E3CDFF1-17FE-411C-BCB3-BDFB46E10668

Q35065308-21A625F2-DE67-4738-872D-E79A4E6DE884

Q35065308-25AB628E-9990-4388-AE27-8CA04F1AA546

Q35065308-27CC036E-3CB3-450A-AEAD-DD735CEF4A1A

Q35065308-2F854360-8883-44B4-9358-7A1AEA81162E

Q35065308-34596ED3-06E4-44E2-A81A-804F639E781B

Q35065308-39D62B84-B5F3-426E-ACF8-D723BA23DEA3

Q35065308-3A8E23C4-4396-4509-8C26-E615011002A5

Q35065308-3DC00D61-2760-4E1B-B82E-B5F1D11D4921

P304

Q35065308-0C032365-B530-4F6B-9073-C8F05D38E367

P31

Q35065308-69C5A6E5-5CF2-4A0B-860B-F03B5A7F6251

P356

Q35065308-24D1F56E-F882-4E23-917E-DEBC59B0536D

P407

Q35065308-461291D8-B8B2-470B-B713-18B4617FB623

P433

Q35065308-D4D8FD2D-2A26-4984-81C4-F3DE0EF4C769

P478

Q35065308-D10D6D63-4EC1-4F4D-B85B-FD2CD79C2BA7

P50

Q35065308-517B1993-31C5-40DD-B9A2-3626171DB041

P577

Q35065308-842B89ED-2C05-4DBB-8AE1-924658358AF7

P5875

Q35065308-7B4D255B-2E30-430E-BCEA-B4E2F939D8D6

P698

Q35065308-8DCFCF01-21AE-45F0-A72E-195E0C98115C

P932

Q35065308-0716117A-B860-4178-9DC8-D21CE5F62B59

P356

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Poly(ADP-ribose) polymerase-de ...... treptozotocin-induced diabetes

@en

P2093

A A Pieper

http://www.w3.org/2001/XMLSchema#string

A Gupta

http://www.w3.org/2001/XMLSchema#string

A Verma

http://www.w3.org/2001/XMLSchema#string

C C Watkins

http://www.w3.org/2001/XMLSchema#string

D J Brat

http://www.w3.org/2001/XMLSchema#string

D K Krug

http://www.w3.org/2001/XMLSchema#string

S Blackshaw

http://www.w3.org/2001/XMLSchema#string

Z Q Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

Studies of streptozotocin-induced insulitis and diabetes

Drugs producing diabetes through damage of the insulin secreting cells

Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase

Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers

Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle.

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.

Poly(ADP-ribose) in the cellular response to DNA damage.

PARP is important for genomic stability but dispensable in apoptosis.

P304

3059-3064

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.96.6.3059

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

96

http://www.w3.org/2001/XMLSchema#string

P50

Solomon Halbert Snyder

P577

1999-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

13212596

http://www.w3.org/2001/XMLSchema#string

P698

10077636

http://www.w3.org/2001/XMLSchema#string

P932

15894

http://www.w3.org/2001/XMLSchema#string