In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development
about
BBS mutations modify phenotypic expression of CEP290-related ciliopathiesRecurrent mutation in the first zinc finger of the orphan nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosaPhotoreceptor cell fate specification in vertebratesThe Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed ConformationBiology and therapy of inherited retinal degenerative disease: insights from mouse modelsRetinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor developmentRegulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRLPotential of Small Molecule-Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis PigmentosaThe orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival.Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: generation of an all-cone Nphp6 hypomorph mouse that mimics the human retinal ciliopathyNetwork-based bioinformatics analysis of spatio-temporal RNA-Seq data reveals transcriptional programs underpinning normal and aberrant retinal development.A statistical framework for consolidating "sibling" probe sets for Affymetrix GeneChip data.RETINOBASE: a web database, data mining and analysis platform for gene expression data on retinaStructure of cone photoreceptors.Unsupervised assessment of microarray data quality using a Gaussian mixture modelMutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX.Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retinaSumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation.Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis.A 350 bp region of the proximal promoter of Rds drives cell-type specific gene expression.Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysisMechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathiesEnRICH: Extraction and Ranking using Integration and Criteria HeuristicsAblation of Kcnj10 expression in retinal explants revealed pivotal roles for Kcnj10 in the proliferation and development of Müller glia.Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy.Combinatorial regulation of photoreceptor differentiation factor, neural retina leucine zipper gene NRL, revealed by in vivo promoter analysis.Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse modelThe transcription factor neural retina leucine zipper (NRL) controls photoreceptor-specific expression of myocyte enhancer factor Mef2c from an alternative promoter.Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursorsVision from next generation sequencing: multi-dimensional genome-wide analysis for producing gene regulatory networks underlying retinal development, aging and diseaseTransformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL.Pushing the envelope of retinal ganglion cell genesis: context dependent function of Math5 (Atoh7).RPGR-associated retinal degeneration in human X-linked RP and a murine model.A method for isolation of cone photoreceptors from adult zebrafish retinaeHave we achieved a unified model of photoreceptor cell fate specification in vertebrates?Retinal pathology of a patient with Goldmann-Favre syndromeMutations in NR2E3 can cause dominant or recessive retinal degenerations in the same familyPositive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication.Regulation of photoreceptor gene expression by Crx-associated transcription factor networkRod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors.
P2860
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P2860
In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development
description
2006 nî lūn-bûn
@nan
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
In vivo function of the orphan ...... mammalian retinal development
@ast
In vivo function of the orphan ...... mammalian retinal development
@en
type
label
In vivo function of the orphan ...... mammalian retinal development
@ast
In vivo function of the orphan ...... mammalian retinal development
@en
prefLabel
In vivo function of the orphan ...... mammalian retinal development
@ast
In vivo function of the orphan ...... mammalian retinal development
@en
P2093
P2860
P356
P1476
In vivo function of the orphan ...... mammalian retinal development
@en
P2093
Artur V Cideciyan
Hong Cheng
Ritu Khanna
Tomas S Aleman
P2860
P304
P356
10.1093/HMG/DDL185
P577
2006-07-25T00:00:00Z