Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.
about
Beyond DNA repair: DNA-PK function in cancerDNA DSB repair pathway choice: an orchestrated handover mechanismDNA-PK: a dynamic enzyme in a versatile DSB repair pathwayThe DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosisChemical Inhibitors of Non-Homologous End Joining Increase Targeted Construct Integration in Cryptococcus neoformansInhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation responseA noncatalytic function of the ligation complex during nonhomologous end joining.Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors.Non-homologous end joining: emerging themes and unanswered questions.Targeting DNA repair pathways for cancer treatment: what's new?Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors.Choosing the right path: does DNA-PK help make the decision?Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells.Polμ deficiency increases resistance to oxidative damage and delays liver aging.Destroying the ring: Freeing DNA from Ku with ubiquitin.Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication productsCorrect end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair ProteinsGenetic variants in DNA double-strand break repair genes and risk of salivary gland carcinoma: a case-control studyN-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV StimulationThe TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP InhibitionDEK is required for homologous recombination repair of DNA breaks.Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.Chemotherapy induced DNA damage response: convergence of drugs and pathwaysDasatinib Inhibits DNA Repair after Radiotherapy Specifically in pSFK-Expressing Tumor Areas in Head and Neck Xenograft Tumors.Defective chromatin recruitment and retention of NHEJ core components in human tumor cells expressing a Cyclin E fragment.MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineeringHistone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade.Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining.End-joining, translocations and cancer.Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing.The major DNA repair pathway after both proton and carbon-ion radiation is NHEJ, but the HR pathway is more relevant in carbon ions.PRKDC mutations in a SCID patient with profound neurological abnormalities.Quantitation of DNA double-strand break resection intermediates in human cells.Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.Unraveling the complexities of DNA-dependent protein kinase autophosphorylation.Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).
P2860
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P2860
Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Inhibition of homologous recom ...... ulated by autophosphorylation.
@ast
Inhibition of homologous recom ...... ulated by autophosphorylation.
@en
type
label
Inhibition of homologous recom ...... ulated by autophosphorylation.
@ast
Inhibition of homologous recom ...... ulated by autophosphorylation.
@en
prefLabel
Inhibition of homologous recom ...... ulated by autophosphorylation.
@ast
Inhibition of homologous recom ...... ulated by autophosphorylation.
@en
P2093
P2860
P356
P1476
Inhibition of homologous recom ...... ulated by autophosphorylation.
@en
P2093
Jessica A Neal
Katheryn Meek
Marc S Wold
Pauline Douglas
Susan P Lees-Miller
P2860
P304
P356
10.1128/MCB.01298-10
P407
P577
2011-02-07T00:00:00Z