Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.
about
Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of painEndogenous opiates and behavior: 2006A single diamagnetic catalyCEST MRI contrast agent that detects cathepsin B enzyme activity by using a ratio of two CEST signalsBi- or multifunctional opioid peptide drugs.Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.Development of potent μ and δ opioid agonists with high lipophilicity.Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide.Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptorsUnderstanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization.The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.Opioid and melanocortin receptors: do they have overlapping pharmacophores?A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities.Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ Opioid Receptor.Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics.Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain.Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs.Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety.Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands.Supramolecular architectures of N-acetyl-L-proline monohydrate and N-benzyl-L-proline.
P2860
Q26863769-93E7B613-969C-4C7F-988E-C4D6E45BA44EQ28752585-BA610B2F-255A-4A49-B1C9-E1632578B4D3Q28833260-F964FBA4-319F-4F82-ADAB-3D4C30753C33Q33767037-34A7A326-4B2F-4477-B071-33A30964A0C9Q34049320-6E6BAE41-75C8-41ED-9C42-82F20A76AC03Q35106084-45DF12C1-B115-4AF8-A4B3-12428F19688EQ35621534-DDB71E69-935F-467C-9AE1-64573CF6F136Q36274630-D35B65CA-8A97-44D6-A754-B17094737ADAQ36508649-05B0D886-B7F8-40AA-A2AF-36F94EE8C66FQ36628300-56E35746-3E55-4A42-AFBD-07C34881BDBEQ36628309-4688091A-1A1B-4E30-8037-4CB6C45EA86FQ36671480-08400DB2-32E6-4D33-B5CE-D143A5030011Q37176219-C0DCBF4C-3FFA-40B4-B3AA-AA01D7E8A1F8Q37183913-F3866A52-598A-41F2-9974-C4A07450EA10Q37218872-B38C852E-AF66-4BEE-BD0C-581D241867B9Q37333022-44DB606A-812B-4792-852A-409E0F379F7BQ37381216-62002076-8492-446C-BA4B-E1866050A62AQ37417012-BA2EE9FC-768E-492F-910F-7BCB06306AC7Q37640669-29F57937-2804-42A9-B02E-AAB7EDD1BD28Q38734980-E969C480-03E2-4FF7-956B-FDEDF997A00FQ38736252-F0955BD4-D68C-4CF0-A77A-2E7E547091B9Q39157737-6E7BF748-7882-42F5-8EDF-DBC4851E5E58Q41942529-14ECA896-2A9B-4982-A404-2A67D1C196A4Q42149810-1D827F84-C0EC-4595-A179-180B8F6E4F2EQ44348169-25FBCADC-D7DB-44AA-88AC-D6CC1ACA2D73Q54659463-8BCC33D5-DD8B-4ECE-A65F-3475C37253DF
P2860
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Design and synthesis of novel ...... -1/CCK-2 receptor antagonists.
@ast
Design and synthesis of novel ...... -1/CCK-2 receptor antagonists.
@en
type
label
Design and synthesis of novel ...... -1/CCK-2 receptor antagonists.
@ast
Design and synthesis of novel ...... -1/CCK-2 receptor antagonists.
@en
prefLabel
Design and synthesis of novel ...... -1/CCK-2 receptor antagonists.
@ast
Design and synthesis of novel ...... -1/CCK-2 receptor antagonists.
@en
P2093
P2860
P356
P1476
Design and synthesis of novel ...... -1/CCK-2 receptor antagonists.
@en
P2093
Frank Porreca
Hamid Badghisi
Josephine Lai
Richard S Agnes
Shou-wu Ma
Victor J Hruby
Yeon Sun Lee
P2860
P304
P356
10.1021/JM050851N
P407
P577
2006-03-01T00:00:00Z