The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
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The pharmacology of neurokinin receptors in addiction: prospects for therapyInvestigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of painConformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor.Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligandsBiological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillaminesOrganic chemistry and biology: chemical biology through the eyes of collaboration.Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptorsDiscovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonistsTachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activationTruncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activitiesDesign of peptide and peptidomimetic ligands with novel pharmacological activity profiles.The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ.Novel cyclic biphalin analogue with improved antinociceptive properties.Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.Synthesis and NMR elucidation of pentacycloundecane-derived hydroxy acid peptides as potential anti-HIV-1 agents
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The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The importance of micelle-boun ...... okinin 1 receptor antagonists.
@en
The importance of micelle-boun ...... okinin 1 receptor antagonists.
@nl
type
label
The importance of micelle-boun ...... okinin 1 receptor antagonists.
@en
The importance of micelle-boun ...... okinin 1 receptor antagonists.
@nl
prefLabel
The importance of micelle-boun ...... okinin 1 receptor antagonists.
@en
The importance of micelle-boun ...... okinin 1 receptor antagonists.
@nl
P2093
P2860
P356
P1476
The importance of micelle-boun ...... okinin 1 receptor antagonists.
@en
P2093
Edita Navratilova
Frank Porreca
Henry I Yamamura
Josephine Lai
Neil E Jacobsen
Padma Nair
Sharif Moye
Shou-wu Ma
Takashi Yamamoto
P2860
P304
P356
10.1021/JM800389V
P407
P577
2008-09-27T00:00:00Z