about
When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility CrisisCharting a Path to Success in Virtual ScreeningHit identification and optimization in virtual screening: practical recommendations based on a critical literature analysisComprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-LactamaseComplementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain InhibitorsChemogenomics: an emerging strategy for rapid target and drug discoveryIspE inhibitors identified by a combination of in silico and in vitro high-throughput screeningThe open access malaria box: a drug discovery catalyst for neglected diseasesBilayer Effects of Antimalarial CompoundsPrivileged Structures Revisited.HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell linesEnhancing reproducibility in cancer drug screening: how do we move forward?Docking Screens for Novel Ligands Conferring New Biology.A focused small-molecule screen identifies 14 compounds with distinct effects on Toxoplasma gondii.Quantification of frequent-hitter behavior based on historical high-throughput screening data.A staged screening of registered drugs highlights remyelinating drug candidates for clinical trialsUsing the BioAssay Ontology for analyzing high-throughput screening data.Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol proteaseData-driven approaches used for compound library design, hit triage and bioactivity modeling in high-throughput screening.High-throughput screening for kinase inhibitors.Diversifying carotenoid biosynthetic pathways by directed evolution.A chemoinformatics analysis of hit lists obtained from high-throughput affinity-selection screening.Diversity-oriented synthesis: exploring the intersections between chemistry and biology.An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF.Increasing the robustness and validity of RNAi screens.Lessons learnt from assembling screening libraries for drug discovery for neglected diseases.Developing and validating predictive decision tree models from mining chemical structural fingerprints and high-throughput screening data in PubChem.Characterization and optimization of a red-shifted fluorescence polarization ADP detection assay.Pooling in high-throughput drug screening.In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitorsA Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates.Estimation of affinities of ligands in mixtures via magnetic recovery of target-ligand complexes and chromatographic analyses: chemometrics and an experimental model.The cellular thermal shift assay for evaluating drug target interactions in cells.The essential roles of chemistry in high-throughput screening triageImproved inhibitor screening experiments by comparative analysis of simulated enzyme progress curves.PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.Mining collections of compounds with Screening Assistant 2Discovery of a novel inhibitor of NAD(P)(+)-dependent malic enzyme (ME2) by high-throughput screening.Mitigating risk in academic preclinical drug discovery.Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Designing screens: how to make your hits a hit.
@ast
Designing screens: how to make your hits a hit.
@en
type
label
Designing screens: how to make your hits a hit.
@ast
Designing screens: how to make your hits a hit.
@en
prefLabel
Designing screens: how to make your hits a hit.
@ast
Designing screens: how to make your hits a hit.
@en
P356
P1476
Designing screens: how to make your hits a hit.
@en
P2093
Mark Namchuk
W Patrick Walters
P2888
P304
P356
10.1038/NRD1063
P577
2003-04-01T00:00:00Z
P6179
1024843331