Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage - Wikidata - awgldk - TriplyDB

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

http://www.wikidata.org/entity/Q35948990

about

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1 Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1 Mechanisms to control rereplication and implications for cancer.Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities The Hect domain E3 ligase Tom1 and the F-box protein Dia2 control Cdc6 degradation in G1 phase Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.CDC6: from DNA replication to cell cycle checkpoints and oncogenesis Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence.Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer.Ultraviolet radiation stress triggers the down-regulation of essential replication factor Mcm10.E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation.Ubiquitin-mediated mRNP dynamics and surveillance prior to budding yeast mRNA export HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold.Replication licensing and the DNA damage checkpoint.The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice.Human proteome-scale structural modeling of E2-E3 interactions exploiting interface motifs.DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation.Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae.Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma.C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint.Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6.CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15 Analysis of re-replication from deregulated origin licensing by DNA fiber spreading Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.Regulation of mRNP dynamics along the export pathway.A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.Apoptosis and oncogenesis: give and take in the BCL-2 family.The emerging role of Mule and ARF in the regulation of base excision repair.Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.Cdc6: a trifunctional AAA+ ATPase that plays a central role in controlling the G(1)-S transition and cell survival.Reprogramming cellular events by poly(ADP-ribose)-binding proteins

P2860

Q24300434-3D9651BD-9B2C-416B-A4AC-F329103DC747 Q24323957-589098FE-B21C-4253-8F74-E1F7FAB09C9C Q24669595-FE15CEAC-02C2-4E77-ABAD-F7BABCE946B2 Q27311420-F3559636-AC09-4382-9315-8D757E1F7B3F Q27658641-1055BB07-AA53-4E0D-9CE0-0B787333B84A Q27930722-569513B5-04BB-4914-9C24-000F60609C24 Q27932166-57B991E3-0079-497E-B952-CA270D357D3D Q28259261-37A992C7-FAE5-4B6C-BEB8-3F14108026E3 Q33342855-544D3249-09D8-4B82-9918-410D908BF9EE Q33395114-12A3D560-CB50-40F6-9DFA-8D172AC8C86E Q33707163-05DFCE13-076E-45D1-93D6-0727B40FBC33 Q34068131-CCB55760-BF3D-4FF3-B752-468F1A524D2E Q34102252-FEAB0B6C-3DE1-46E7-84FD-6AC551B207E5 Q34298040-145F7A95-DC8A-4D96-A8A0-4E5E8591F144 Q34547673-64A0AEF8-7AD6-4644-A0DB-19D9BA52DD39 Q35092727-FCAC3BED-F449-46E4-8593-C722161E74CC Q35679564-408B1B68-B7CC-4135-AE1D-31C72692B136 Q35762987-3DB0620D-D033-4607-B909-3EDB1BD37AB8 Q35774953-3B3BE87A-8966-4E83-902E-96AB70586D09 Q35786131-27140DF5-B717-4237-8092-7448D9142B5D Q35849098-19C4499C-68F7-4F4E-B084-55742F8175DB Q36108956-2C823D5F-A5AE-44E5-895D-080C9389B784 Q36188284-B8BE8476-FD8F-4754-8357-422F88471CDD Q36510551-ED944216-1F87-4D4A-B9D7-5A672A92AF43 Q36534379-CD4FD3F5-CE5A-4F6B-B8A0-5AF46E74E3D4 Q36695607-FF2824B1-3757-48FC-8567-38163AE4071F Q36869434-B178D598-8238-4C39-908E-2134A51D5BC5 Q36902911-D289DA18-53A2-4B26-959B-1532B85A9203 Q37041809-D67E4429-C206-45B1-B341-405E2A711A72 Q37049530-33B34D41-0C67-4393-A3BB-A115E616958E Q37131104-50AF77E0-B29F-40D9-8081-91B32DFB1F1D Q37163577-29C72A11-93B7-4276-96BA-6DED5B3E5EF6 Q37336985-09A1377D-F69A-4F2E-940B-72406E31D3CE Q37402856-3ACFBDD7-28C9-41A2-B9BA-4EF751BB200F Q37620424-2532AF4D-B384-4722-A2A5-8C1AF405FD21 Q37828794-8F8A5A7B-7179-49C6-8744-9FA15C54FFBC Q37897323-1387D7B1-15C3-4FB6-A7FC-399291A22652 Q37989861-037C35FE-4100-4F81-BEB8-69016281C95D Q38036244-DAF50050-27AD-402B-9974-445912607508 Q38069879-10EF3619-194F-40FE-A2B2-038C3C43960A

P2860

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

http://www.wikidata.org/entity/Q35948990

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

2007年论文

@zh

2007年论文

@zh-cn

name

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

@ast

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

@en

type

label

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

@ast

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

@en

prefLabel

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

@ast

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

@en

P1433

Q35948990-20FED601-102A-4849-BC76-5AB83C0F468B

P1476

Q35948990-D47DE83E-39B8-46EB-9185-F799F5419755

P2093

Q35948990-0C678DFC-0F62-44DA-898F-78050E259F50

Q35948990-122D483F-6976-4650-BE89-7133FA5B821C

Q35948990-35A9CC59-5B4D-4733-A89B-ECD6604670FD

Q35948990-49817896-DB90-458A-AE72-1D3D3FE73771

Q35948990-6B35246B-B761-40DB-B3D9-2A872E600A6C

Q35948990-897EFCAC-5364-44C4-8C6B-07805DD0A236

Q35948990-9285E29D-B7D2-4239-997E-45480FFAD70B

P2860

Q35948990-090A4073-9E50-4248-B0D1-7D0E43209F3F

Q35948990-09ABC81D-BD0A-4B6A-8597-442C2C0E53E4

Q35948990-0A8B4A7D-9E60-4F33-84E8-9359CA47AFD3

Q35948990-0AEB748E-C13D-443A-BEBA-E84116A2ECCF

Q35948990-0F818A6E-505A-4542-9153-DE4D2607B693

Q35948990-10A2A04A-931D-403F-8173-9A6A981854ED

Q35948990-13BEB6A0-2345-4BAD-A592-E3F8F4A1234B

Q35948990-1501D441-D838-4201-A494-42B5FF445A9E

Q35948990-15577969-B5AA-4988-BDCC-5D65D51219B4

Q35948990-18BE2F7C-4681-4531-B3D4-BE61385B1B5E

P304

Q35948990-58D8F865-7430-421D-A227-02658D45A023

P31

Q35948990-60D92F2A-0AFD-4002-929F-8631C38E3523

P356

Q35948990-37CB30E9-4B1E-4E35-BA43-636E3C8CFA98

P433

Q35948990-AA33B1F0-6E58-4FC0-A754-42016AF7C1CD

P478

Q35948990-91C4DB5E-776A-4CE4-B66B-451269F5922D

P577

Q35948990-15E4E1F2-84BC-4BD6-86F6-55A4F1ACEC44

P5875

Q35948990-4C17E160-410C-47BC-B574-CF05DB8DB6D3

P698

Q35948990-582027CE-A06E-4B02-8C38-066711285BD0

P921

Q35948990-557483E8-A5AD-4118-B011-3A94F7865426

P932

Q35948990-6169D3A9-2308-4827-9F3B-AF9E3C2D6DAB

P356

MBC.E07-02-0173

P1433

Molecular Biology of the Cell

P1476

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

@en

P2093

Chiajung Karen Lu

http://www.w3.org/2001/XMLSchema#string

Evelyn Kow

http://www.w3.org/2001/XMLSchema#string

Jeanette Gowen Cook

http://www.w3.org/2001/XMLSchema#string

Jonathan R Hall

http://www.w3.org/2001/XMLSchema#string

K Scott Luce

http://www.w3.org/2001/XMLSchema#string

Kathleen R Nevis

http://www.w3.org/2001/XMLSchema#string

Qing Zhong

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones.

The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.

Disruption of mechanisms that prevent rereplication triggers a DNA damage response

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

P304

3340-3350

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1091/MBC.E07-02-0173

http://www.w3.org/2001/XMLSchema#string

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

18

http://www.w3.org/2001/XMLSchema#string

P577

2007-06-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6269108

http://www.w3.org/2001/XMLSchema#string

P698

17567951

http://www.w3.org/2001/XMLSchema#string

P921

P932

1951745

http://www.w3.org/2001/XMLSchema#string