Critical contribution of the MDM2 acidic domain to p53 ubiquitination.
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Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 bindingAn essential function of the extreme C-terminus of MDM2 can be provided by MDMXMutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stabilityAberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2Role of EBNA-3 Family Proteins in EBV Associated B-cell LymphomagenesisDeubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activityInhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stressMDM2 and MDMX: Alone and together in regulation of p53Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transferThe anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain.An observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomasMDM2 oligomers: antagonizers of the guardian of the genome.Controlling the Mdm2-Mdmx-p53 Circuit.MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.Autoactivation of the MDM2 E3 ligase by intramolecular interaction.MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional outputNucleolar stress with and without p53.Mechanism of p53 stabilization by ATM after DNA damage.The central region of HDM2 provides a second binding site for p53.HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication.Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implicationsA novel anticancer therapy that simultaneously targets aberrant p53 and Notch activities in tumorsDistinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin.Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress.Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-MycSignaling to p53: ribosomal proteins find their way.Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.Abnormal MDMX degradation in tumor cells due to ARF deficiencyThe RING finger domain of MDM2 is essential for MDM2-mediated TGF-beta resistance.MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 functionThe Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo.MDM2 is a novel E3 ligase for HIV-1 Vif.Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity.Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity.
P2860
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P2860
Critical contribution of the MDM2 acidic domain to p53 ubiquitination.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Critical contribution of the MDM2 acidic domain to p53 ubiquitination.
@ast
Critical contribution of the MDM2 acidic domain to p53 ubiquitination.
@en
type
label
Critical contribution of the MDM2 acidic domain to p53 ubiquitination.
@ast
Critical contribution of the MDM2 acidic domain to p53 ubiquitination.
@en
prefLabel
Critical contribution of the MDM2 acidic domain to p53 ubiquitination.
@ast
Critical contribution of the MDM2 acidic domain to p53 ubiquitination.
@en
P2093
P2860
P1476
Critical contribution of the MDM2 acidic domain to p53 ubiquitination.
@en
P2093
Dmitri Wiederschain
Hidehiko Kawai
Zhi-Min Yuan
P2860
P304
P356
10.1128/MCB.23.14.4939-4947.2003
P407
P577
2003-07-01T00:00:00Z