Abnormal MDMX degradation in tumor cells due to ARF deficiency - Wikidata - awgldk - TriplyDB

Abnormal MDMX degradation in tumor cells due to ARF deficiency

Abnormal MDMX degradation in tumor cells due to ARF deficiency

http://www.wikidata.org/entity/Q35791309

about

Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators Role of MDM2 and MDMX in DNA repair MDM2 oligomers: antagonizers of the guardian of the genome.Autoinhibition of MDMX by intramolecular p53 mimicry The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding.The Mdm network and its regulation of p53 activities: a rheostat of cancer risk.Restoring the tumour suppressive function of p53 as a parallel strategy in melanoma therapy.MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond.Mdmx promotes genomic instability independent of p53 and Mdm2.Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells.MDMX under stress: the MDMX-MDM2 complex as stress signals hub

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P2860

Abnormal MDMX degradation in tumor cells due to ARF deficiency

http://www.wikidata.org/entity/Q35791309

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Abnormal MDMX degradation in tumor cells due to ARF deficiency

@ast

Abnormal MDMX degradation in tumor cells due to ARF deficiency

@en

type

label

Abnormal MDMX degradation in tumor cells due to ARF deficiency

@ast

Abnormal MDMX degradation in tumor cells due to ARF deficiency

@en

prefLabel

Abnormal MDMX degradation in tumor cells due to ARF deficiency

@ast

Abnormal MDMX degradation in tumor cells due to ARF deficiency

@en

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P1476

Abnormal MDMX degradation in tumor cells due to ARF deficiency

@en

P2093

B Li

http://www.w3.org/2001/XMLSchema#string

D Gilkes

http://www.w3.org/2001/XMLSchema#string

D Pernazza

http://www.w3.org/2001/XMLSchema#string

H Lawrence

http://www.w3.org/2001/XMLSchema#string

J Chen

http://www.w3.org/2001/XMLSchema#string

N Lawrence

http://www.w3.org/2001/XMLSchema#string

Q Cheng

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X Li

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P2860

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

MDMX regulation of p53 response to ribosomal stress

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.

DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms.

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

MDM2 interacts with MDMX through their RING finger domains

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination

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3721-3732

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scholarly article

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10.1038/ONC.2011.534

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32

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31

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2011-11-28T00:00:00Z

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22120712

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3290737

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