Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. - Wikidata - awgldk - TriplyDB

Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.

Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.

http://www.wikidata.org/entity/Q35131032

about

Insulin receptor signaling in normal and insulin-resistant states Phosphoinositides: Key modulators of energy metabolism The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs.Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia.Ablation of PI3K p110-α prevents high-fat diet-induced liver steatosis p110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming Independently of p110α Kinase Activity.Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent Alterations in lipid signaling underlie lipodystrophy secondary to AGPAT2 mutations.Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus.Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.PIK3CA(H1047R)- and Her2-initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling.Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome.Hyperglycemia and Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) Inhibitors in Phase I Trials: Incidence, Predictive Factors, and Management Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance.Dissociating fatty liver and diabetes Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders.Knockout mouse models of insulin signaling: Relevance past and future Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating hepatic insulin signalling.CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.The selective PI3Kα inhibitor BYL719 as a novel therapeutic option for neuroendocrine tumors: Results from multiple cell line models.Characterization of a novel p110β-specific inhibitor BL140 that overcomes MDV3100-resistance in castration-resistant prostate cancer cells.BYL719, a new α-specific PI3K inhibitor: single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma.FOXO transcription factors at the interface of metabolism and cancer.PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength.PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter.Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.The Role of Class IA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunits in Glioblastoma.

P2860

Q26823171-58F7D921-F731-44C8-9860-F2F6C12D8F80 Q27022953-58117E17-D83E-4EE8-8900-AA572873BF72 Q27851848-C99FEFFF-F861-4079-BB8B-C300112E2C51 Q28591921-0141DC3D-0856-4689-8206-2C7847BB8667 Q30430507-282DD22A-348F-4EE3-89FB-C24B312777D6 Q33577861-E39FD79E-D876-4B58-9054-C2C4234DC315 Q34508976-E6142888-4441-4132-AAF2-45F575E22701 Q34797066-32BE969D-BBC2-45CC-9F62-7F86EA7EB25D Q35064323-29EBC34B-218A-4AB6-AD92-BB5D850D8EF1 Q35165157-6CF90944-1D10-48B6-BC86-F8DE7F203D48 Q35260766-DA57B906-BDD9-4AB9-B6C7-30FB0E14954A Q35745395-661EEF90-B8BB-4506-A2D2-11E9A9035A2C Q35796978-F70F3E96-587F-4D4E-9FE7-FB0B45F58420 Q36033370-1B6E63B3-D5F9-457C-8BF1-65C3ECE26304 Q36062493-FAA0B1C0-5BF7-4927-B144-8C2B498242F5 Q36339534-A9AEBE07-94AA-4927-9EFE-4E7C78BC9B2C Q36363079-609DF66E-B04E-4E59-A2CE-E4F6D275DBE2 Q36560572-836C0D61-16C6-4E6C-A809-6964EAC779CD Q36771317-3A58C9B0-0629-45F5-B231-FA78F09CB944 Q36884668-2CCF4079-D993-4025-A650-B01E95ED38B6 Q36978609-542840EC-9DF6-4F01-97D3-FAAC662E84F0 Q36990083-671DE6EC-C0B6-42FA-9054-6067CB8D146E Q37064604-61617CC7-375D-4C8F-A224-9541C7E26ABC Q37091101-C9B54854-81F0-44C1-88DF-CA5F39DE244F Q37303694-EE832080-7180-4C35-9420-6005E69C4E62 Q38050214-833CB40B-8AB1-493E-AAE4-E059B6022AB3 Q38193084-F23B175F-CCE0-483D-8506-D6334876BF68 Q38205763-7D5E037D-0D75-4FB4-99BC-38F28E4DE792 Q38302507-0CF22ED9-0B03-40F8-81FD-94ACC4FE1F50 Q38672092-89993819-7C28-4649-B5C7-A4FF56A5D1CB Q38695102-4039B7BE-08FF-4444-B298-C98111B86193 Q38699761-7B57B1CA-5DB7-4E53-BEAD-87D1B9D6DC42 Q38981617-45E8E8AE-37D8-4EE4-A346-F24D1E1D356C Q39385262-5D91D08F-BAEA-4122-B82D-AC6FA5AFC854 Q40810931-29FA62FE-5CBB-418C-956B-75E60BCDC481 Q42129503-BE603111-4B26-4090-B054-C08B990277FF Q42441155-1C852C07-146A-4D49-B477-2F9FCDCBBB4C Q42812320-CCF8B88C-6490-4224-BA67-907B3D4783CD Q47298942-E4FC96B9-CD7A-4EAC-B262-6A3E8F8A0184 Q47868509-A8AFC2DA-9984-4D2E-BA0B-A191EFE45170

P2860

Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.

http://www.wikidata.org/entity/Q35131032

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

Specific roles of the p110alph ...... ling and metabolic regulation.

@ast

Specific roles of the p110alph ...... ling and metabolic regulation.

@en

type

label

Specific roles of the p110alph ...... ling and metabolic regulation.

@ast

Specific roles of the p110alph ...... ling and metabolic regulation.

@en

prefLabel

Specific roles of the p110alph ...... ling and metabolic regulation.

@ast

Specific roles of the p110alph ...... ling and metabolic regulation.

@en

P1433

Q35131032-C294C0C9-ACB8-4A22-9E21-6EBE2427FA14

P1476

Q35131032-87CB51F9-283E-44DF-83C3-719548F75AD4

P2093

Q35131032-10B11F07-7F96-41EC-BC73-7066C2DA1022

Q35131032-1EBF40A1-74FD-4B90-A8ED-CAD354329666

Q35131032-290298EE-986C-460B-9234-C8CF59491DDF

Q35131032-29F3FAC4-D879-4D07-A7F5-9A7BF9295C41

Q35131032-8A067F08-851D-405A-83B1-A449D37B3158

Q35131032-A490CF4A-E6C1-4314-BC33-94E6AC271EC7

Q35131032-A5A49A6C-C774-42F8-97A0-001AFEF25661

Q35131032-D7291E09-A6DD-40BF-94AF-F9F1D1C7391D

Q35131032-DCB3EA5E-66BE-47DC-A6C4-E784BE7921F7

Q35131032-F39BF926-7294-4913-A3D3-0D357C128EA3

P2860

Q35131032-10A59396-3D29-49C7-AA45-95992249420A

Q35131032-15097FA9-A8B8-4391-86CF-A8D59443976D

Q35131032-177D4142-9C64-478F-B058-159B2E92360F

Q35131032-1B235BD6-536F-4AEB-9DE5-32732A7B924C

Q35131032-1F4883D5-CB60-4FF0-8846-F38B08A26B6D

Q35131032-21B920FD-0D84-4775-B89D-01C68861ED85

Q35131032-25DB673A-FB3A-4393-AE3F-E000DF2C323A

Q35131032-2B30E120-0F49-4C13-9B96-C160E9BB2C47

Q35131032-3179EBD7-EEFF-4962-ADC7-341CD0187424

Q35131032-38DAA8A5-CE2B-4C2E-9E66-FC4237A50D97

P304

Q35131032-87A7741E-27E3-4844-A0F8-7EF6E88E38AF

P31

Q35131032-3151B806-ED7D-4783-B097-A7C04700D2B2

P356

Q35131032-C7CEDEDE-9E94-45AD-80F8-50F53B72676A

P433

Q35131032-FE23977C-88D3-4268-B444-6B439515D293

P478

Q35131032-F9E4E385-F9AF-459D-8633-3D55B1E79901

P50

Q35131032-B123EFAF-DE11-4133-A1CC-8ADC42F56CDD

P577

Q35131032-A2107758-4656-4D46-8A5C-599984D70E0B

P5875

Q35131032-2B32B081-4BD1-4AE5-8409-8C6B9217C264

P698

Q35131032-3EDF949B-CEA6-495E-AE10-67C7A19DF084

P932

Q35131032-56A1CB0F-FE21-49FF-8420-64C49E247061

P356

J.CMET.2010.02.002

P1433

Cell Metabolism

P1476

Specific roles of the p110alph ...... ling and metabolic regulation.

@en

P2093

Graham Smyth

http://www.w3.org/2001/XMLSchema#string

Jean J Zhao

http://www.w3.org/2001/XMLSchema#string

Jonathon Winnay

http://www.w3.org/2001/XMLSchema#string

Mini P Sajan

http://www.w3.org/2001/XMLSchema#string

Pixu Liu

http://www.w3.org/2001/XMLSchema#string

Robert V Farese

http://www.w3.org/2001/XMLSchema#string

Ryo Suzuki

http://www.w3.org/2001/XMLSchema#string

Tatsuya Kondo

http://www.w3.org/2001/XMLSchema#string

Thien T Tran

http://www.w3.org/2001/XMLSchema#string

Tomoichiro Asano

http://www.w3.org/2001/XMLSchema#string

P2860

Mechanism by which metformin reduces glucose production in type 2 diabetes

Role of AMP-activated protein kinase in mechanism of metformin action

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Phosphoinositide kinases

P304

220-230

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.CMET.2010.02.002

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

11

http://www.w3.org/2001/XMLSchema#string

P50

P577

2010-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

41668878

http://www.w3.org/2001/XMLSchema#string

P698

20197055

http://www.w3.org/2001/XMLSchema#string

P932

3144706

http://www.w3.org/2001/XMLSchema#string