The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistence
about
Kaposi's Sarcoma Herpesvirus Genome PersistenceCrystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral LatencyKaposi sarcoma herpes virus latency associated nuclear antigen protein release the G2/M cell cycle blocks by modulating ATM/ATR mediated checkpoint pathwayThe first endogenous herpesvirus, identified in the tarsier genome, and novel sequences from primate rhadinoviruses and lymphocryptovirusesA protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylationPhosphorylation of the chromatin binding domain of KSHV LANAIRF-4-mediated CIITA transcription is blocked by KSHV encoded LANA to inhibit MHC II presentation.The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence.Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence.Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection.Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGASKSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.Identification of Kaposi's sarcoma-associated herpesvirus LANA regions important for episome segregation, replication, and persistence.A short sequence immediately upstream of the internal repeat elements is critical for KSHV LANA mediated DNA replication and impacts episome persistenceEpigenetic Pathways of Oncogenic Viruses: Therapeutic Promises.Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence.Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.ORF73 LANA homologs of RRV and MneRV2 contain an extended RGG/RG-rich nuclear and nucleolar localization signal that interacts directly with importin β1 for non-classical nuclear import.A role for the internal repeat of the Kaposi's sarcoma-associated herpesvirus latent nuclear antigen in the persistence of an episomal viral genome.Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation.Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells.
P2860
Q26738483-F3611900-D502-4296-B5D1-B58428A8699EQ27680412-DF2FC297-4717-4687-A8FD-D0166356CFF6Q28540116-BC58886F-3332-4AEB-ACB9-3301C99556FDQ28657883-AAD0E43A-E503-43A9-9D48-34F7DCC5E252Q34179693-B3BD8C16-35F9-47D5-9931-551FD690285EQ34186981-E74F360C-F643-4853-8C3B-FCFB562511F3Q34456086-1B80CB73-5034-4151-A9B9-9CB58CFE9009Q35034278-B52DE6D2-4A80-4330-99C4-890F9D20BE5AQ36301221-79A30C4D-3E69-4619-9049-D4560919A8CFQ36363318-2862A86F-801B-44ED-BBC9-7AC4613CA692Q36506932-6FE49CA2-E800-45B4-AB5C-FFE466D674CEQ36646579-2B175328-3B24-43F6-A68E-AD18E74EBB7DQ36676548-82918290-AE95-4F31-81C8-87750EDC9D9EQ37254389-EC111DE1-7AA2-4A46-B03F-8B0A5FE2F2D8Q37380221-FB5B15E0-8A80-4E6F-9928-4B3991FD65ACQ38692795-2BEE1996-138B-4511-8258-4E2063ABA979Q39265271-5DB5BCA7-EDE3-4E9F-83DD-1DA8A11A4A5FQ40041231-A1793EC5-A8BA-49A1-B9CC-10B05D12C3C5Q40066566-341EE18C-27C4-4ADB-90E8-FE9A3B4DBC33Q40605014-CC69BCD9-2E27-4F23-96DE-B98B17B5F764Q40698869-E44A7C29-1018-4595-8FEE-5EF7D76757B0Q54217632-6A35C5FA-8C4C-4B9C-8D9F-0377B745878D
P2860
The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistence
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The internal Kaposi's sarcoma- ...... al role on episome persistence
@ast
The internal Kaposi's sarcoma- ...... al role on episome persistence
@en
type
label
The internal Kaposi's sarcoma- ...... al role on episome persistence
@ast
The internal Kaposi's sarcoma- ...... al role on episome persistence
@en
prefLabel
The internal Kaposi's sarcoma- ...... al role on episome persistence
@ast
The internal Kaposi's sarcoma- ...... al role on episome persistence
@en
P2860
P356
P1433
P1476
The internal Kaposi's sarcoma- ...... al role on episome persistence
@en
P2093
Erika De León Vázquez
Kenneth M Kaye
P2860
P304
P356
10.1128/JVI.00304-11
P407
P577
2011-05-18T00:00:00Z