Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration. - Wikidata - awgldk - TriplyDB

Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration.

Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration.

http://www.wikidata.org/entity/Q35150064

about

MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling Axon degeneration: Molecular mechanisms of a self-destruction pathway A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress Spy1 Protein Mediates Phosphorylation and Degradation of SCG10 Protein in Axonal Degeneration.Characterization of Leber Congenital Amaurosis-associated NMNAT1 Mutants SARM1 activation triggers axon degeneration locally via NAD⁺ destruction Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration SCG10 is a JNK target in the axonal degeneration pathway.Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.Sarm1-mediated axon degeneration requires both SAM and TIR interactions NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.Axonal degeneration as a therapeutic target in the CNS.Concepts for regulation of axon integrity by enwrapping glia.Wallerian degeneration: an emerging axon death pathway linking injury and disease.Signaling mechanisms regulating Wallerian degeneration.Mechanisms of developmental neurite pruning.In vitro models of axon regeneration.Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration.Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice JUN is important for ocular hypertension-induced retinal ganglion cell degeneration.The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2.A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson's disease.Avian axons undergo Wallerian degeneration after injury and stress.Inactivation of Bcl-2 through IκB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE).

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Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration.

http://www.wikidata.org/entity/Q35150064

description

2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Image-based screening identifi ...... nase 3 in axonal degeneration.

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Image-based screening identifi ...... nase 3 in axonal degeneration.

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type

label

Image-based screening identifi ...... nase 3 in axonal degeneration.

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Image-based screening identifi ...... nase 3 in axonal degeneration.

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Image-based screening identifi ...... nase 3 in axonal degeneration.

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Image-based screening identifi ...... nase 3 in axonal degeneration.

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Journal of Biological Chemistry

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Image-based screening identifi ...... nase 3 in axonal degeneration.

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Bhupinder Vohra

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Jayne Marasa

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Jeffrey Milbrandt

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Josiah Gerdts

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Yo Sasaki

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P2860

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

Statistical methods for analysis of high-throughput RNA interference screens

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration.

Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling.

Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth.

Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.

Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway.

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10.1074/JBC.M111.250472

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32

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3151046

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