The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. - Wikidata - awgldk - TriplyDB

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.

http://www.wikidata.org/entity/Q41475482

about

MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin A fly's view of neuronal remodeling RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons.Developmental Function of the PHR Protein RPM-1 Is Required for Learning in Caenorhabditis elegans.Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress NMNAT: It's an NAD+ synthase… It's a chaperone… It's a neuroprotector.Preserve and protect: maintaining axons within functional circuits.Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex Absence of SARM1 rescues development and survival of NMNAT2-deficient axons.Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components.Sculpting neural circuits by axon and dendrite pruning TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance.Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK Sarm1-mediated axon degeneration requires both SAM and TIR interactions JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila.Sodium and potassium currents influence Wallerian degeneration of injured Drosophila axons.Axonal trafficking of NMNAT2 and its roles in axon growth and survival in vivo.MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.Diversification of NAD biological role: the importance of location.Mitochondrial dysfunction and NAD(+) metabolism alterations in the pathophysiology of acute brain injury.Concepts for regulation of axon integrity by enwrapping glia.Drosophila models of neuronal injury Diverse cellular and molecular modes of axon degeneration.Wallerian degeneration: an emerging axon death pathway linking injury and disease.Signaling mechanisms regulating Wallerian degeneration.A unified cell biological perspective on axon-myelin injury.Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.Mechanisms of distal axonal degeneration in peripheral neuropathies.

P2860

Q21089746-766C06F9-639C-4473-AF5B-233E725DA90B Q26752306-A86ECF9E-5582-44D8-BDF0-5683576D2F31 Q27314937-9008811A-413A-4BE2-B147-F79664CF5049 Q28068381-F856F8F5-3F79-482B-A5B7-28F0952D7719 Q28538585-32303984-C53B-417B-BE7B-B87DCFF864E8 Q30252985-822205DE-39F9-4ECE-9638-D4FC480F487B Q30395751-8FFBF0CA-EFE3-46B3-BBCA-F374F2EDAB91 Q30543899-91C6B941-92DF-472E-8CE6-AB8FAF00A4BB Q30638030-87122069-A7D0-4380-96BD-A22492973EC4 Q30656970-C37C852E-FFAB-4CD1-9D61-0BC61AED8245 Q33770371-D7FAA2D2-0485-431C-806D-64E0DE7C39F3 Q33919735-41CCD8CE-2096-4D54-A8D8-18CA7C4EC655 Q33985200-B7828B43-1743-4D14-B91A-15E96E901388 Q34555880-A4040350-35D2-44A5-AFCD-9BA733128E1A Q34575680-93844A37-485E-4722-A269-58AAB042C6FB Q34683242-8FE10810-1510-4A51-B83B-4DEBE5365BE4 Q35275832-E000412D-9453-4CBD-B33A-0579D889F3F2 Q35472270-66E8BAEA-2990-40A6-9B15-E717397CC73E Q36099459-CE71060A-6290-4917-BC09-E93215E6C953 Q36344881-8560A43C-019A-407D-AF6D-CF64AD482FCE Q36840516-649B53BB-5A0E-45FE-A8D7-02DFA0472F40 Q36932922-90CD7F25-F765-4EB3-AC37-3A73F803863E Q36978295-D0E7F2A3-6098-4041-A6C7-ED8A3B6E7C30 Q37093933-BCF560B4-BBF2-4BED-9219-9724E54F1325 Q37141102-1309C076-A7A3-4A3C-995B-45251432B6D1 Q37282538-7E691BB8-B844-401B-B453-3A2F89AA66FC Q37282607-FB913642-C954-4351-BFB5-8F78D5A46FC7 Q37345123-6A42E26D-9390-4518-B5F6-8665128D3F4D Q37534326-4048F49C-BFFA-479A-BC7F-5B29F115713E Q37590373-67BDFB9A-CDC3-4967-A742-2352543014D7 Q38121170-D245FEAA-D6AC-4846-AFF6-46EF95422AB9 Q38170006-A1CE3AFB-86DA-4EF2-B9BB-BF9241A60942 Q38175969-95E7D4C8-FD61-4ADF-9FA3-F028F48BDCC7 Q38194948-4DD344FA-9286-4ED5-BEB9-B2FEF17E5BC6 Q38208077-E4F85209-B01C-42AF-B81E-9C638476D7EF Q38212791-5E845541-5DEC-48E0-8A3F-A708C3686F80 Q38218414-6AB7D5D5-ABA8-4129-9DB7-1AAC1CB5C8D0 Q38237032-BD6E9FFE-AF53-4EAE-B188-1D873D4D15C6 Q38265736-E6E69C9D-7F27-498B-B843-D0C6F57E7746 Q38330759-AF678339-4281-41A9-9D32-520155A8902F

P2860

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.

http://www.wikidata.org/entity/Q41475482

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.

@en

type

label

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.

@en

prefLabel

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.

@en

P1433

Q41475482-2DE453A1-C14C-4C2B-A4BB-1747613AB15E

P1476

Q41475482-97115929-E67E-4131-98B3-71ADE8DBD29A

P2093

Q41475482-31F61ABE-34FC-40C0-96A9-86D5BB602A41

Q41475482-5D8C6C9A-D3BB-4A2F-ABF7-34BACB863E1F

Q41475482-71CDF706-BA33-4ACA-9854-11EBE7F3E095

Q41475482-932FD2FA-B0AB-4965-8C6C-A57EBC767B69

Q41475482-CB9830D5-9F2D-40CD-B449-85EE002610FF

P2860

Q41475482-02634C59-F2E5-41DA-8FFA-508A8A346E1D

Q41475482-038B9292-911A-42C8-AE5E-3C26D3C300AC

Q41475482-05A0FBF0-DF82-4AC7-A1B6-5239F2894C57

Q41475482-0F2FABB1-8B58-48FD-9B36-F46A6889DF1D

Q41475482-1250F65B-6189-48D4-AE04-6CB52B8AEF1D

Q41475482-1D267810-9694-4E36-B397-4C36086AEFB4

Q41475482-1FCF23B4-B2F0-4372-B7FF-32E8CEC9DBC9

Q41475482-2640209E-5FE7-461B-B18D-EF02E7621C3B

Q41475482-27F1AD37-12DB-42BE-ADAB-19866889EA6B

Q41475482-285F110E-C57F-447B-BF64-C23C7620BD40

P304

Q41475482-4088DFB9-DA93-494E-8365-B2139865CAF7

P31

Q41475482-192BAB5D-C1A5-4EE3-AB79-ED59D654CBC2

P356

Q41475482-56BBEE3A-1E5D-4878-BE8A-965EB56BAF1B

P433

Q41475482-1953308E-7CAF-4BF9-BE0D-D84FBC853311

P478

Q41475482-1269CA7D-F693-48BF-BCB3-A89B74FD3321

P577

Q41475482-B74B7D4D-75E4-4EA7-86AD-920FD1224192

P5875

Q41475482-8BE2A826-0FB4-48CF-AA82-2D4E5504762E

P698

Q41475482-93B06AF3-2823-4F2C-99FB-51C55E198E4C

P921

Q41475482-7D7569EE-74E2-42E0-8970-4AE2B747B166

P932

Q41475482-72DA481B-D05A-44EF-91C6-D7300CC7FE4F

P356

J.CELREP.2013.04.013

P1433

P1476

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.

@en

P2093

Aaron DiAntonio

http://www.w3.org/2001/XMLSchema#string

Bogdan Beirowski

http://www.w3.org/2001/XMLSchema#string

Elisabetta Babetto

http://www.w3.org/2001/XMLSchema#string

Emilie V Russler

http://www.w3.org/2001/XMLSchema#string

Jeffrey Milbrandt

http://www.w3.org/2001/XMLSchema#string

P2860

Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons

The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein

The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.

Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.

P304

1422-1429

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.CELREP.2013.04.013

http://www.w3.org/2001/XMLSchema#string

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

3

http://www.w3.org/2001/XMLSchema#string

P577

2013-05-09T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

236691072

http://www.w3.org/2001/XMLSchema#string

P698

23665224

http://www.w3.org/2001/XMLSchema#string

P921

P932

3671584

http://www.w3.org/2001/XMLSchema#string