Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability.
about
O-GlcNAcylation regulates EZH2 protein stability and functionBRCA1 is a negative modulator of the PRC2 complexTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsResetting a functional G1 nucleus after mitosisEZH2 in Bladder Cancer, a Promising Therapeutic TargetDiverse involvement of EZH2 in cancer epigeneticsThe role of EZH2 in tumour progressionJNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenicPRC2/EED-EZH2 complex is up-regulated in breast cancer lymph node metastasis compared to primary tumor and correlates with tumor proliferation in situA polycomb group protein is retained at specific sites on chromatin in mitosisInhibition of EZH2 degradation as a novel approach to overcome drug resistance in acute myeloid leukemia.Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7.NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes.A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.Chemical probes targeting epigenetic proteins: Applications beyond oncology.Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cellsRegulation and Role of EZH2 in CancerConditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival.Inner workings and regulatory inputs that control Polycomb repressive complex 2YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERKPolycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.Signals of Ezh2, Src, and Akt Involve in myostatin-Pax7 pathways regulating the myogenic fate determination during the sheep myoblast proliferation and differentiationPCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression.Drosophila Cyclin G and epigenetic maintenance of gene expression during developmentM phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers.Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells.Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells.Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic strokeCyclin-dependent kinase-mediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migration.Molecular pathways: environmental estrogens activate nongenomic signaling to developmentally reprogram the epigenome.Regulation and role of post-translational modifications of enhancer of zeste homologue 2 in cancer developmentSET for life: biochemical activities and biological functions of SET domain-containing proteinsGSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers.CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy.Sensing cellular states--signaling to chromatin pathways targeting Polycomb and Trithorax group function.Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2.Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer.Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.
P2860
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P2860
Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Cyclin-dependent kinase 1 (CDK ...... Ezh2) regulates its stability.
@ast
Cyclin-dependent kinase 1 (CDK ...... Ezh2) regulates its stability.
@en
type
label
Cyclin-dependent kinase 1 (CDK ...... Ezh2) regulates its stability.
@ast
Cyclin-dependent kinase 1 (CDK ...... Ezh2) regulates its stability.
@en
prefLabel
Cyclin-dependent kinase 1 (CDK ...... Ezh2) regulates its stability.
@ast
Cyclin-dependent kinase 1 (CDK ...... Ezh2) regulates its stability.
@en
P2860
P356
P1476
Cyclin-dependent kinase 1 (CDK ...... Ezh2) regulates its stability.
@en
P2093
P2860
P304
28511-28519
P356
10.1074/JBC.M111.240515
P407
P577
2011-06-09T00:00:00Z