Phosphotyrosyl mimetics in the development of signal transduction inhibitors.
about
The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domainResidues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding.Synthesis of phosphatase-stable, cell-permeable peptidomimetic prodrugs that target the SH2 domain of Stat3Preparation of orthogonally protected (2S, 3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of Polo-box domain-binding peptides.Progress towards the development of SH2 domain inhibitors.Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold.Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position.Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAKDevelopment of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative AgentsDesign and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl-bis-pivaloyloxymethyl (POM) prodrug form.Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs.Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor designPhosphatase-Stable Phosphoamino Acid Mimetics That Enhance Binding Affinities with the Polo-Box Domain of Polo-like Kinase 1.Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure.Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.Computational Insight into Protein Tyrosine Phosphatase 1B Inhibition: A Case Study of the Combined Ligand- and Structure-Based Approach.Direct C-H difluoromethylenephosphonation of arenes and heteroarenes with bromodifluoromethyl phosphonate via visible-light photocatalysis.Synthesis of 1-Difluoroalkylated Isoquinolines via Palladium-Catalyzed Radical Cascade Difluoroalkylation-Cyclization of Vinyl Isocyanides with Bromodifluoroacetic Derivatives.Copper-Catalyzed Reaction of Trifluoromethylketones with Aldehydes via a Copper Difluoroenolate.Palladium-Catalyzed Remote Aryldifluoroalkylation of Alkenyl Aldehydes.Gold-Catalyzed Highly Selective Photoredox C(sp(2) )-H Difluoroalkylation and Perfluoroalkylation of Hydrazones.Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics.Current chemical biology tools for studying protein phosphorylation and dephosphorylation.Grb2 signaling in cell motility and cancerCarbonylation of Difluoroalkyl Bromides Catalyzed by PalladiumPalladium-catalyzed phosphonyldifluoromethylation of alkenes with bromodifluoromethylphosphonateCopper-catalyzed cross-coupling of bromozinc-difluoromethylphosphonate with iodo/bromo-aryl triazenesPalladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid DerivativesAddition of Electrophilic Radicals to 2-Benzyloxyglycals: Synthesis and Functionalization of Fluorinated α-C-Glycosides and Derivatives
P2860
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P2860
Phosphotyrosyl mimetics in the development of signal transduction inhibitors.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Phosphotyrosyl mimetics in the development of signal transduction inhibitors.
@ast
Phosphotyrosyl mimetics in the development of signal transduction inhibitors.
@en
type
label
Phosphotyrosyl mimetics in the development of signal transduction inhibitors.
@ast
Phosphotyrosyl mimetics in the development of signal transduction inhibitors.
@en
prefLabel
Phosphotyrosyl mimetics in the development of signal transduction inhibitors.
@ast
Phosphotyrosyl mimetics in the development of signal transduction inhibitors.
@en
P356
P1476
Phosphotyrosyl mimetics in the development of signal transduction inhibitors.
@en
P2093
Kyeong Lee
Terrence R Burke
P304
P356
10.1021/AR020127O
P407
P577
2003-06-01T00:00:00Z