Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members

Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members

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http://www.wikidata.org/entity/Q35160453
Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1.Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest.Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastineA plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2.Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis.Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death.Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified.Microtubule destabilising agents: far more than just antimitotic anticancer drugs.Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1.Combined therapeutic effects of vinblastine and Astragalus saponins in human colon cancer cells and tumor xenograft via inhibition of tumor growth and proangiogenic factors.Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance.Distinct signaling pathways of microtubule inhibitors--vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively.Perturbing mitosis for anti-cancer therapy: is cell death the only answer?
P2860

Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members

Item
http://www.wikidata.org/entity/Q35160453
description
2006 nî lūn-bûn
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2006 թուականի Մարտին հրատարակուած գիտական յօդուած
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2006 թվականի մարտին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
@zh-mo
2006年論文
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2006年论文
@wuu
name
Vinblastine-induced apoptosis ...... specific Bcl-2 family members
@ast
Vinblastine-induced apoptosis ...... specific Bcl-2 family members
@en
type
label
Vinblastine-induced apoptosis ...... specific Bcl-2 family members
@ast
Vinblastine-induced apoptosis ...... specific Bcl-2 family members
@en
prefLabel
Vinblastine-induced apoptosis ...... specific Bcl-2 family members
@ast
Vinblastine-induced apoptosis ...... specific Bcl-2 family members
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
Vinblastine-induced apoptosis ...... specific Bcl-2 family members
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932