Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.
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The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines.Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via insulin-like growth factor-1 receptor-independent mechanismMechanism of the promotion of steatotic HepG2 cell apoptosis by cholesterolPaclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor.Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.MPT0B169, a New Antitubulin Agent, Inhibits Bcr-Abl Expression and Induces Mitochondrion-Mediated Apoptosis in Nonresistant and Imatinib-Resistant Chronic Myeloid Leukemia Cells.Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins.Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins.Mitotic cell death caused by follistatin-like 1 inhibition is associated with up-regulated Bim by inactivated Erk1/2 in human lung cancer cellsCritical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death.Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified.The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis.The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation.Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers.SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models.Mcl-1 dynamics influence mitotic slippage and death in mitosis.BCL-W is a regulator of microtubule inhibitor-induced mitotic cell death.Small peptide substrates and high resolution peptide gels for the analysis of site-specific protein phosphorylation and dephosphorylation.Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine.Cis-trimethoxy resveratrol induces intrinsic apoptosis via prometaphase arrest and prolonged CDK1 activation pathway in human Jurkat T cells.Perturbing mitosis for anti-cancer therapy: is cell death the only answer?CDK1 switches mitotic arrest to apoptosis by phosphorylating Bcl-2/Bax family proteins during treatment with microtubule interfering agents.
P2860
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P2860
Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Cdk1/cyclin B plays a key role ...... reeing Bak from sequestration.
@ast
Cdk1/cyclin B plays a key role ...... reeing Bak from sequestration.
@en
type
label
Cdk1/cyclin B plays a key role ...... reeing Bak from sequestration.
@ast
Cdk1/cyclin B plays a key role ...... reeing Bak from sequestration.
@en
prefLabel
Cdk1/cyclin B plays a key role ...... reeing Bak from sequestration.
@ast
Cdk1/cyclin B plays a key role ...... reeing Bak from sequestration.
@en
P2093
P2860
P1476
Cdk1/cyclin B plays a key role ...... reeing Bak from sequestration.
@en
P2093
David T Terrano
Timothy C Chambers
P2860
P304
P356
10.1016/J.BCP.2011.10.008
P407
P577
2011-10-18T00:00:00Z