Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1.

Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1.

Item
http://www.wikidata.org/entity/Q35168200
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysisp27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysisXic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication.The origin of CDK regulationActivation of the anaphase promoting complex by HTLV-1 tax leads to senescence.HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex.Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication.Proliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching.A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT.Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia.Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest.Upregulation of CRM1 relates to neuronal apoptosis after traumatic brain injury in adult rats.Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation.Regulation of nuclear transport and degradation of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1.
P2860

Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1.

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http://www.wikidata.org/entity/Q35168200
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2000 nî lūn-bûn
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name
Nuclear accumulation of cyclin ...... or the destruction of p27Xic1.
@ast
Nuclear accumulation of cyclin ...... or the destruction of p27Xic1.
@en
type
label
Nuclear accumulation of cyclin ...... or the destruction of p27Xic1.
@ast
Nuclear accumulation of cyclin ...... or the destruction of p27Xic1.
@en
prefLabel
Nuclear accumulation of cyclin ...... or the destruction of p27Xic1.
@ast
Nuclear accumulation of cyclin ...... or the destruction of p27Xic1.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Nuclear accumulation of cyclin ...... or the destruction of p27Xic1.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932