Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
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The HTLV-1 Tax interactomeHost-pathogen interactome mapping for HTLV-1 and -2 retrovirusesHTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progressionSkp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescenceViruses associated with human cancerHTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZControversies in targeted therapy of adult T cell leukemia/lymphoma: ON target or OFF target effects?BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cellsCREB--a real culprit in oncogenesisComplex cell cycle abnormalities caused by human T-lymphotropic virus type 1 Tax.Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex.Hematopoietic stem cells and retroviral infection.Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway.HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes.Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence marker.NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ.KSHV vCyclin counters the senescence/G1 arrest response triggered by NF-κB hyperactivation.Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-based gene expression analysis.HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.HTLV-I tax increases genetic instability by inducing DNA double strand breaks during DNA replication and switching repair to NHEJ.The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasomeInactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax proteinMaking sense out of antisense transcription in human T-cell lymphotropic viruses (HTLVs).Move or die: the fate of the Tax oncoprotein of HTLV-1.Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax.Human T-cell leukemia virus type 1 Tax protein down-regulates pre-T-cell receptor alpha gene transcription in human immature thymocytesHTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.How the DNA damage response determines the fate of HTLV-1 Tax-expressing cells.Novel ARF/p53-independent senescence pathways in cancer repression.HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex.Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax.Inducible nitric oxide synthase mediates DNA double strand breaks in Human T-Cell Leukemia Virus Type 1-induced leukemia/lymphoma.Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway.Cotranscriptional Chromatin Remodeling by Small RNA Species: An HTLV-1 PerspectiveComplex role of microRNAs in HTLV-1 infections.HTLV-I Tax-Mediated Inactivation of Cell Cycle Checkpoints and DNA Repair Pathways Contribute to Cellular Transformation: "A Random Mutagenesis Model"Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1.Human T-cell leukemia virus type 1 infection leads to arrest in the G1 phase of the cell cycleImaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors.Induction of p21(CIP1/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization
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P2860
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
@ast
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
@en
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
@nl
type
label
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
@ast
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
@en
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
@nl
prefLabel
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
@ast
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
@en
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
@nl
P2860
P356
P1433
P1476
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.
@en
P2093
Chou-Zen Giam
Yu-Liang Kuo
P2860
P304
P356
10.1038/SJ.EMBOJ.7601054
P407
P577
2006-04-06T00:00:00Z