Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite.
about
The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!Recent developments in drug discovery for leishmaniasis and human African trypanosomiasisDiscovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal StructureBiological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective InhibitorsIdentification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaigncAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite TransmissionAntiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug RepositioningScaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitorsNew compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets.Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness.Cyclic AMP Regulates Social Behavior in African Trypanosomes.Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs.Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs.The utility of yeast as a tool for cell-based, target-directed high-throughput screening.Yeast as a potential vehicle for neglected tropical disease drug discovery.Drug target identification in protozoan parasites.Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.Signaling Strategies of Malaria Parasite for Its Survival, Proliferation, and Infection during Erythrocytic Stage.Drugs for neglected diseases: part I.Interview with Future Medicinal Chemistry's US Senior Editor, Iwao Ojima. Interview by Issac Bruce.Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.Bioinformatics Analysis and Functional Prediction of Transmembrane Proteins inRational Selection of Anti-Microbial Drug Targets: Unique or Conserved?
P2860
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P2860
Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Phosphodiesterase inhibitors a ...... ved between host and parasite.
@ast
Phosphodiesterase inhibitors a ...... ved between host and parasite.
@en
type
label
Phosphodiesterase inhibitors a ...... ved between host and parasite.
@ast
Phosphodiesterase inhibitors a ...... ved between host and parasite.
@en
prefLabel
Phosphodiesterase inhibitors a ...... ved between host and parasite.
@ast
Phosphodiesterase inhibitors a ...... ved between host and parasite.
@en
P2860
P356
P1476
Phosphodiesterase inhibitors a ...... ved between host and parasite.
@en
P2093
Geert Jan Sterk
Thomas Seebeck
P2860
P304
P356
10.4155/FMC.11.77
P50
P577
2011-08-01T00:00:00Z