TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease - Wikidata - awgldk - TriplyDB

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q35203740

about

Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation How do immune cells support and shape the brain in health, disease, and aging?Innate immunity in Alzheimer's disease: a complex affair Microglia development and function APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective Lipopolysaccharide from Rhodobacter sphaeroides Attenuates Microglia-Mediated Inflammation and Phagocytosis and Directs Regulatory T Cell Response Temporal-logic analysis of microglial phenotypic conversion with exposure to amyloid-β.Phagocytosis of microglia in the central nervous system diseases Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP/PS1 transgenic mice.Sequence-dependent internalization of aggregating peptides Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques The evolving biology of microglia in Alzheimer's disease.A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients.Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro Fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of TLR4 and p38 MAPK signaling.The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain.Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.Alginate-Derived Oligosaccharide Inhibits Neuroinflammation and Promotes Microglial Phagocytosis of β-Amyloid.Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson's disease The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory.Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide.Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease.Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia.The bradykinin B1 receptor regulates Aβ deposition and neuroinflammation in Tg-SwDI mice.Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.Activated cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar β-amyloid by up-regulating lipoprotein lipase expression Scutellarin attenuates hypertension-induced expression of brain Toll-like receptor 4/nuclear factor kappa B.Different TLR4 expression and microglia/macrophage activation induced by hemorrhage in the rat spinal cord after compressive injury.Neuroinflammation and copper in Alzheimer's disease.Toll-Like Receptor 2 Recognizes Orientia tsutsugamushi and Increases Susceptibility to Murine Experimental Scrub Typhus Structure-Activity Relationship in TLR4 Mutations: Atomistic Molecular Dynamics Simulations and Residue Interaction Network Analysis.The neuroendocrine control of the innate immune system in health and brain diseases.Clearance of amyloid-β peptides by microglia and macrophages: the issue of what, when and where.Regulation of microglia activation and deactivation by nuclear receptors.Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology.The role of vitamin D in Alzheimer's disease: possible genetic and cell signaling mechanisms.Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease.

P2860

Q26738336-F88F4B94-782C-4536-8E06-F29D8458B17B Q26747005-43A51217-0951-4180-A7F3-D95BEB10B276 Q26995364-5FD97C5F-C67F-4109-ADE3-C398B32A51D8 Q27006944-936554CE-13C3-45A7-A616-935E5C31A510 Q27316453-5CF87208-3D39-405E-961E-75B4490B3C69 Q28085213-8D9CC898-1BBD-475F-9BC5-668C79D77E09 Q28268463-A14E8AFE-2401-4480-B7D1-BAD5138BF0BE Q33359453-37F61FD7-DD7C-40D9-9660-49D450F99ADC Q33574527-0813BEF8-C1AA-426E-AFDC-CEE24A160F66 Q34319766-3D101B54-2426-4B12-BB76-AB66ECC79A1B Q34429979-7C57E5DB-AF6A-4B05-A4A0-C340E31710FA Q34801378-BB6584C5-A051-45DE-903A-A440D5173438 Q35030015-0BC92E6C-F388-4C0C-9368-E94C1011F9F4 Q35064995-15294544-6508-4E2D-B5B3-FFA8795FA59E Q35106556-9D780A7A-081E-404F-9244-702A939660A9 Q35531082-AD8FDC28-EC4E-4CBF-8DF2-7FF5553E8F1B Q35544629-2407E8EA-0F54-452C-BB56-05E94246CCC3 Q35599843-0B5B7015-7B06-4840-875A-8F2D2EC988C8 Q35674014-7E9473C9-DE72-4E2E-B7C5-CA6C7A818137 Q36096572-D0DC2697-551E-45BD-A16C-18D3A4D6B5BC Q36123393-05CF90F9-C50A-4854-91AD-7937E7080441 Q36222441-FDD1E338-007B-4AA2-AD2F-13BDD4CDD10D Q36348374-E2CBE966-438B-462D-935D-D96E3B5C3778 Q36421994-77A740F7-8784-4054-9EC8-3890DC8F5BE4 Q36618073-45369EA1-A49C-4DC9-AEA3-84CED8A3A57C Q36817597-36977844-7AF9-4925-846D-31B83B3FC077 Q36985041-6FE073C3-5E73-4D3E-8C30-E10B3C1FBCDE Q37116609-CFF244F1-A265-4CDA-8A8D-9A4AFCFC75E4 Q37214684-C05035DC-83CE-475C-BF50-548CE8F5B985 Q37239794-E428DF9C-B93B-4D36-9E27-05A8BEA5B3BF Q37356682-655836FE-AB7E-4EE5-9251-A33F7A71B724 Q37393152-C73344BC-B32B-4E68-8053-88C252E7D7A7 Q37424974-8AFBECC9-7D58-44D0-97E7-03EF175C2615 Q37686656-650135CB-CCE5-49C0-8510-5ACA6D8BFA36 Q38020956-4D655BAE-F8BC-48D1-8213-9E78529442E3 Q38021993-877E184F-BC2F-408E-BB9A-FFF7A06EF873 Q38044319-0E77840C-87EE-42CE-BBF9-AC17014BB305 Q38061480-51684029-3EB9-46F2-8984-E5A24D56439F Q38074422-627F90A0-8A8B-4D77-95A5-1D0C3185BD55 Q38108433-9D9DA74D-EAAA-435D-B565-5F00C2862F3A

P2860

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q35203740

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

TLR4 mutation reduces microgli ...... e model of Alzheimer's disease

@ast

TLR4 mutation reduces microgli ...... e model of Alzheimer's disease

@en

type

label

TLR4 mutation reduces microgli ...... e model of Alzheimer's disease

@ast

TLR4 mutation reduces microgli ...... e model of Alzheimer's disease

@en

prefLabel

TLR4 mutation reduces microgli ...... e model of Alzheimer's disease

@ast

TLR4 mutation reduces microgli ...... e model of Alzheimer's disease

@en

P1433

Q35203740-389FF4C2-83AA-4A4D-8D48-A8CF49B9BAB3

P1476

Q35203740-A08C0F3F-F15E-487D-8409-6A1AD98C60D6

P2093

Q35203740-02BA6088-13AC-4EF9-90CF-80D10C015947

Q35203740-11D15C67-6E13-4E06-9643-90EAE120C440

Q35203740-17524EAC-334D-4C24-B35F-E4FFBDF3B349

Q35203740-3C28CC1D-C2A4-4947-93E0-5BFD11395FB5

Q35203740-41703357-B8E6-452A-9FBA-0B014548F49A

Q35203740-62F7160E-65D6-4FE6-8807-89087871980A

Q35203740-7ED6363C-81AE-40F6-A23D-E7AF2B9EA2E6

Q35203740-E35F6C2D-7852-45A6-8A31-027B5F1253FD

Q35203740-F4613409-4687-4D7F-A3BC-33642876A125

P2860

Q35203740-0750837F-DD90-444B-A5F0-2DDE9F9C309B

Q35203740-08EA193C-D6C1-49C2-BF9C-E90A9BBB944B

Q35203740-1EC5F751-960D-4B44-9EFD-07AA7ED610E7

Q35203740-26443EC5-47AE-44E3-BC6B-B9CE1F7AD2DA

Q35203740-30ED5AAC-2488-4A4D-BD48-4916B7DF6D95

Q35203740-3296A2EC-B035-48FE-A6CC-1487119F4EED

Q35203740-33644F3A-8882-4C86-B53E-DA13BE15CC35

Q35203740-47C758A1-494D-4FE8-A331-EE6F6EBD9BD7

Q35203740-4F328032-6532-4BC5-ABBB-15D796508AE9

Q35203740-56F957F0-8E0E-4157-9806-19AD06EC7CDD

P2888

Q35203740-F2C214CB-2D63-4A90-90F6-72E61911C751

P304

Q35203740-F973EA59-1625-4572-9C3D-4AA442FF67BC

P31

Q35203740-C4008986-8B6B-463C-AA55-2D8983E1CD10

P356

Q35203740-A6BFFA29-D1CB-44A0-B224-DDEC8EDF2C42

P478

Q35203740-53CC9F26-7949-4D00-A792-30ADFBEF009C

P50

Q35203740-DF891A9B-12C4-4BF7-9193-F52D24D1D94E

P577

Q35203740-B82C96D9-4FDA-443C-89EF-281229AA6449

P5875

Q35203740-60A82F97-3E9B-4636-8371-B1FB01F1B3D0

P6179

Q35203740-A111FE40-BC42-467B-82C7-EF97345600E4

P698

Q35203740-5F0E7F93-B986-460E-AB85-FF4075FB5ACE

P921

Q35203740-0DA188CC-CCBB-4CEA-A551-3A30E0B7A2A6

Q35203740-679AA836-5618-45C7-81B7-53D621004B68

Q35203740-AA7B4F08-0CC2-40BD-8B40-F000D32D5030

P932

Q35203740-FC37B0D6-66F7-4316-A02E-E54297C8FCBC

P356

P1433

Journal of Neuroinflammation

P1476

TLR4 mutation reduces microgli ...... e model of Alzheimer's disease

@en

P2093

Hong-Duck Kim

http://www.w3.org/2001/XMLSchema#string

Jamaal A Rehman

http://www.w3.org/2001/XMLSchema#string

Jeong-Eun Lim

http://www.w3.org/2001/XMLSchema#string

Jinghong Kou

http://www.w3.org/2001/XMLSchema#string

Jingji Jin

http://www.w3.org/2001/XMLSchema#string

Kazuki Tahara

http://www.w3.org/2001/XMLSchema#string

Ken-ichiro Fukuchi

http://www.w3.org/2001/XMLSchema#string

Min Song

http://www.w3.org/2001/XMLSchema#string

Robert Lalonde

http://www.w3.org/2001/XMLSchema#string

P2860

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice.

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Pattern recognition receptors and inflammation

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

A specific amyloid-beta protein assembly in the brain impairs memory

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

P2888

P304

92

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1186/1742-2094-8-92

http://www.w3.org/2001/XMLSchema#string

P478

8

http://www.w3.org/2001/XMLSchema#string

P50

Abhinandan Pattanayak

P577

2011-08-09T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51557988

http://www.w3.org/2001/XMLSchema#string

P6179

1052121893

http://www.w3.org/2001/XMLSchema#string

P698

21827663

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease

Toll-like receptor

P932

3169468

http://www.w3.org/2001/XMLSchema#string