The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication - Wikidata - awgldk - TriplyDB

The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

http://www.wikidata.org/entity/Q35205554

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Unraveling DNA helicases. Motif, structure, mechanism and function Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1 Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae.Mutations in DNA replication genes reduce yeast life span.Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM The MER3 helicase involved in meiotic crossing over is stimulated by single-stranded DNA-binding proteins and unwinds DNA in the 3' to 5' direction.Mechanisms by which Bloom protein can disrupt recombination intermediates of Okazaki fragment maturation.RecQ helicases: guardian angels of the DNA replication fork.Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.RecQ helicases: suppressors of tumorigenesis and premature aging.The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants.Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structure.CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45.Purification and enzymatic characterization of Gallus gallus BLM helicase.

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P2860

The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

http://www.wikidata.org/entity/Q35205554

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2000 nî lūn-bûn

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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

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2000年論文

@zh-hant

2000年論文

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2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

@ast

The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

@en

type

label

The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

@ast

The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

@en

prefLabel

The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

@ast

The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

@en

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Genes & Development

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The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

@en

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H Yan

http://www.w3.org/2001/XMLSchema#string

J Graham

http://www.w3.org/2001/XMLSchema#string

S Liao

http://www.w3.org/2001/XMLSchema#string

P2860

Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells

Nuclear structure in normal and Bloom syndrome cells

The Bloom's syndrome gene product is a 3'-5' DNA helicase

The Bloom's syndrome gene product is homologous to RecQ helicases

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1

The Bloom's syndrome gene product interacts with topoisomerase III

Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast.

Replication focus-forming activity 1 and the Werner syndrome gene product.

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2570-2575

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scholarly article

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10.1101/GAD.822400

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20

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14

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2000-10-01T00:00:00Z

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11040210

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