The new face of active receptor bound arrestin attracts new partners.
about
Arrestins: ubiquitous regulators of cellular signaling pathwaysThe structural basis of arrestin-mediated regulation of G-protein-coupled receptorsActivation-dependent conformational changes in {beta}-arrestin 2.The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated Akt activation.How a small change in retinal leads to G-protein activation: initial events suggested by molecular dynamics calculations.Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by lightIdentification of receptor binding-induced conformational changes in non-visual arrestins.Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 bindingDifferential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin.Endocytic adaptors--social networking at the plasma membrane.Arrestins regulate cell spreading and motility via focal adhesion dynamicsA single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding.Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorderEach rhodopsin molecule binds its own arrestinConformation of receptor-bound visual arrestin.Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activationArrestins and two receptor kinases are upregulated in Parkinson's disease with dementia.Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sitesVisual and both non-visual arrestins in their "inactive" conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm.Visual arrestin binding to microtubules involves a distinct conformational changeThe differential engagement of arrestin surface charges by the various functional forms of the receptor.Regulation of arrestin binding by rhodopsin phosphorylation level.How and why do GPCRs dimerize?MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.Rich tapestry of G protein-coupled receptor signaling and regulatory mechanisms.JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinasesThe role of arrestin alpha-helix I in receptor binding.Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs.Custom-designed proteins as novel therapeutic tools? The case of arrestins.Synthetic biology with surgical precision: targeted reengineering of signaling proteins.Structural determinants of arrestin functionsβ-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia.Extensive shape shifting underlies functional versatility of arrestins.Overview of different mechanisms of arrestin-mediated signaling.Beyond traditional pharmacology: new tools and approaches.Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors.Arrestins: Critical Players in Trafficking of Many GPCRs.β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycleMonitoring agonist-promoted conformational changes of beta-arrestin in living cells by intramolecular BRET.Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity.
P2860
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P2860
The new face of active receptor bound arrestin attracts new partners.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The new face of active receptor bound arrestin attracts new partners.
@ast
The new face of active receptor bound arrestin attracts new partners.
@en
type
label
The new face of active receptor bound arrestin attracts new partners.
@ast
The new face of active receptor bound arrestin attracts new partners.
@en
prefLabel
The new face of active receptor bound arrestin attracts new partners.
@ast
The new face of active receptor bound arrestin attracts new partners.
@en
P1433
P1476
The new face of active receptor bound arrestin attracts new partners.
@en
P2093
Eugenia V Gurevich
Vsevolod V Gurevich
P304
P356
10.1016/S0969-2126(03)00184-9
P577
2003-09-01T00:00:00Z