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Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laserStructure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptideCrystal structure of pre-activated arrestin p44Visualization of arrestin recruitment by a G-protein-coupled receptorRhodopsin TM6 can interact with two separate and distinct sites on arrestin: evidence for structural plasticity and multiple docking modes in arrestin-rhodopsin bindingIdentification of receptor binding-induced conformational changes in non-visual arrestins.Functional competence of a partially engaged GPCR-β-arrestin complexG protein-coupled receptors--recent advancesPhospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.Dilution of dipolar interactions in a spin-labeled, multimeric metalloenzyme for DEER studies.Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsinEngineering visual arrestin-1 with special functional characteristicsCritical role of the central 139-loop in stability and binding selectivity of arrestin-1.The β-Arrestins: Multifunctional Regulators of G Protein-coupled ReceptorsFunctional map of arrestin binding to phosphorylated opsin, with and without agonist.Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 bindingJNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinasesFunctional map of arrestin-1 at single amino acid resolutionRole of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking.Structural determinants of arrestin functionsExtensive shape shifting underlies functional versatility of arrestins.Overview of different mechanisms of arrestin-mediated signaling.Peptide mini-scaffold facilitates JNK3 activation in cellsIdentification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes.Structural mechanism of GPCR-arrestin interaction: recent breakthroughs.Nanodiscs in Membrane Biochemistry and Biophysics.Structural evidence for the role of polar core residue Arg175 in arrestin activation.The effect of phosphorylation on arrestin-rhodopsin interaction in the squid visual system.Formation and decay of the arrestin·rhodopsin complex in native disc membranes.Crystal structure of a common GPCR-binding interface for G protein and arrestin.Targeting individual GPCRs with redesigned nonvisual arrestins.Self-association of arrestin family members.Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains.Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant.Arrestins in apoptosis.Therapeutic potential of small molecules and engineered proteins.Arrestin-dependent activation of JNK family kinasesEnhanced phosphorylation-independent arrestins and gene therapy.The rhodopsin-arrestin-1 interaction in bicelles.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Conformation of receptor-bound visual arrestin.
@ast
Conformation of receptor-bound visual arrestin.
@en
type
label
Conformation of receptor-bound visual arrestin.
@ast
Conformation of receptor-bound visual arrestin.
@en
prefLabel
Conformation of receptor-bound visual arrestin.
@ast
Conformation of receptor-bound visual arrestin.
@en
P2093
P2860
P50
P356
P1476
Conformation of receptor-bound visual arrestin.
@en
P2093
Miyeon Kim
Nathan S Alexander
Ned Van Eps
Oliver P Ernst
Sergey A Vishnivetskiy
Susan M Hanson
Takefumi Morizumi
Whitney M Cleghorn
Xuanzhi Zhan
P2860
P304
18407-18412
P356
10.1073/PNAS.1216304109
P407
P577
2012-10-22T00:00:00Z