Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study. - Wikidata - awgldk - TriplyDB

Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.

Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.

http://www.wikidata.org/entity/Q35229738

about

Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy Targeting the Notch signaling pathway in cancer therapeutics A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a pediatric brain tumor consortium report Results of a phase 1 trial combining ridaforolimus and MK-0752 in patients with advanced solid tumours.Inhibition of notch signaling in combination with Paclitaxel reduces platinum-resistant ovarian tumor growth.γ-secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway Adaptive dose-finding studies: a review of model-guided phase I clinical trials.Assay of lapatinib in murine models of cigarette smoke carcinogenesis.Notch inhibitors for cancer treatment.Management of diffuse pontine gliomas in children: recent developments.A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma.Notch signaling in pediatric soft tissue sarcomas Notch signaling in serous ovarian cancer.Challenges of clinical trial design for targeted agents against pediatric leukemias.Crosstalk between glioma-initiating cells and endothelial cells drives tumor progression.Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation Notch signaling activation in pediatric low-grade astrocytoma Notch suppresses angiogenesis and progression of hepatic metastases Gamma secretase inhibitor enhances sensitivity to doxorubicin in MDA-MB-231 cells.The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma.Myc proteins in brain tumor development and maintenance.Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition Improving the outcome for children with cancer: Development of targeted new agents.DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation.Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study.Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors.Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.Optimizing drug development of anti-cancer drugs in children using modelling and simulation.Notch Signaling Mediates Skeletal Muscle Atrophy in Cancer Cachexia Caused by Osteosarcoma.Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition Vasculogenic mimicry in small cell lung cancer.The rationale for targeted therapies in medulloblastoma.Cancer stem cells in glioma: challenges and opportunities.Targeting notch signaling pathway in cancer: clinical development advances and challenges Molecular sub-group-specific immunophenotypic changes are associated with outcome in recurrent posterior fossa ependymoma Drug development and clinical trials--the path to an approved cancer drug.Pediatric neuro-oncology: current status and future directions.Pharmacotherapeutic management of pediatric gliomas : current and upcoming strategies.Notch signalling in adult neurons: a potential target for microtubule stabilization.

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P2860

Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.

http://www.wikidata.org/entity/Q35229738

description

2011 nî lūn-bûn

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2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Phase I trial of MK-0752 in ch ...... brain tumor consortium study.

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Phase I trial of MK-0752 in ch ...... brain tumor consortium study.

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P356

JCO.2011.35.7806

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Journal of Clinical Oncology

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Phase I trial of MK-0752 in ch ...... brain tumor consortium study.

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P2093

Amar Gajjar

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Arzu Onar-Thomas

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Clinton F Stewart

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James M Boyett

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James Olson

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Larry E Kun

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Lars M Wagner

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Richard J Gilbertson

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Roger J Packer

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Stewart Goldman

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P2860

Is there a role for Notch signalling in human breast cancer?

In vivo analysis of choroid plexus morphogenesis in zebrafish

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

Identification of human brain tumour initiating cells

t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway

Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro

Notch signaling in the nervous system. Pieces still missing from the puzzle.

Development and Notch signaling requirements of the zebrafish choroid plexus.

Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.

ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease.

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3529-3534

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10.1200/JCO.2011.35.7806

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26

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29

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Sridharan Gururangan

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2011-08-08T00:00:00Z

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21825264

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phase I clinical trial

P932

3179253

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