The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs
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Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligandsIonotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkersStructure, function, and modulation of GABA(A) receptorsPentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepinesThe Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Molecular tools for GABAA receptors: High affinity ligands for β1-containing subtypes.Alcohol selectivity of β3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the α+β- subunit interface in αβ3δ GABAA receptors.The anxiolytic effects of a Valerian extract is based on valerenic acid.Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor.Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.Influence of GABA(A) receptor α subunit isoforms on the benzodiazepine binding siteFunctional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.The Direct Actions of GABA, 2'-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries.Distinct properties of glycine receptor β+/α- interface: unambiguously characterizing heteromeric interface reconstituted in homomeric proteinIdentification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interfaceSubtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors.Novel positive allosteric modulators of GABAA receptors with anesthetic activity.Luteolin inhibits GABAA receptors in HEK cells and brain slicesZolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface.Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site.GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophreniaA novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface.Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes.GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome.Molecular mode of action of CGS 9895 at α1 β2 γ2 GABAA receptors.Towards functional selectivity for α6β3γ2 GABAA receptors: a series of novel pyrazoloquinolinones.Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site.Analysis of γ-aminobutyric acid (GABA) type A receptor subtypes using isosteric and allosteric ligands.Modifications of diflunisal and meclofenamate carboxyl groups affect their allosteric effects on GABAA receptor ligand binding.NMDA Receptors and NO:cGMP Signaling Pathway Mediate the Diazepam-Induced Sensitization to Withdrawal Signs in Mice.GABAA receptor: Positive and negative allosteric modulators.
P2860
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P2860
The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs
@ast
The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs
@en
type
label
The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs
@ast
The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs
@en
prefLabel
The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs
@ast
The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs
@en
P2093
P2860
P1476
The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs
@en
P2093
Isabella Sarto-Jackson
Joachim Ramerstorfer
Roman Furtmüller
Zdravko Varagic
P2860
P304
P356
10.1523/JNEUROSCI.5012-10.2011
P407
P577
2011-01-01T00:00:00Z